Neuroscience 2001 Abstract
| Presentation Number: | 642.13 |
|---|---|
| Abstract Title: | NEURAL INTEGRATOR AND DIFFERENTIATOR STUDIED IN A MAMMALIAN MODEL OF NONASSOCIATIVE LEARNING. |
| Authors: |
Young, D. L.*1,2
; Siniaia, M.2
; Poon, C. S.2
1Dept Mechanical Engineering, MIT, Cambridge, MA 2Div Hlth Sci & Technol, MIT, Cambridge, MA |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Associative, nonassociative and skill learning & memory systems |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Autonomic<br />-- Respiratory regulation |
| Session: |
642. Animal cognition and behavior: associative, nonassociative and skill learning and memory systems--conditioning and nonassociative learning Poster |
| Presentation Time: | Tuesday, November 13, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall TT-30 |
| Keywords: | vagus, synaptic depression, habituation, learning and memory |
Integration and differentiation of afferent signals are fundamental to certain kinematic and dynamic operations in the brain. The recent demonstrations of both integral (Poon et al., NeuroReport, 10:2261, 1999) and differential (Poon et al., Neurosci. Lett. 284:5, 2000) computations in the mammalian respiratory central pattern generator (RCPG) provide a useful model of such brain calculus. In particular, the differentiator-like adaptations of the Hering-Breuer (HB) vagal reflex of the RCPG have been experimentally linked to parallel neural pathways (Siniaia et al., J. Physiol. 523:479, 2000) that conform to the classic dual-process model of nonassociative learning—with habituation in the primary central pathway for vagal proprioceptive feedback and desensitization in a secondary, pontine pathway with a tonic input. This neural differentiator structure is supported by the recent demonstration of synaptic short-term depression (STD) in the vagal and pontine pathways (Siniaia et al., SFN 2000, 2001 Meetings) corresponding to the habituation and desensitization of the HB reflex, respectively. Here we present an experimental demonstration of this dual-process neural differentiator structure by using stroboscopic vagal activation of the RCPG, which produced phase-dependent interference of the respiratory rhythm thus allowing precise resolution of the vagal and pontine adaptation components in vivo. Results showed that the dual-process nonassociative learning structure of HB reflex produced a second-order neural differentiator as the algebraic complement of neural integrators in the vagal-pontine pathways.
Supported by NIH grants 1R01HL60064 and 1F31MH12697
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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