Neuroscience 2005 Abstract
| Presentation Number: | 565.5 |
|---|---|
| Abstract Title: | Regional white and gray matter volumetric growth differences in children with persistent versus recovered stuttering: an MRI (VBM) study. |
| Authors: |
Chang, S.*1,3
; Erickson, K. I.2,3
; Ambrose, N. G.1
1Speech and Hearing Science, Univ. of Illinois, Champaign, IL 2Psych., Univ. of Illinois, Champaign, IL 3IL, 901 S. Sixth St, 61820, |
| Primary Theme and Topics |
Disorders of the Nervous System - Developmental Disorders -- Genetic |
| Session: |
565. Developmental Brain Disorders Poster |
| Presentation Time: | Monday, November 14, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # VV24 |
| Keywords: | Speech , Language, childhood disorders, development |
The cause of stuttering remains unknown. Several studies indicate the presence of subtle differences in neurophysiological function and structure in adults who stutter (AWS) compared to normally fluent controls, supporting past hypotheses of aberrant speech motor and sensory function related to stuttering. To date, such findings have not been replicated in children, although stuttering starts and more often than not resolves on its own during childhood. The mechanisms of stuttering persistence and recovery can best be revealed through investigating children, as they are less likely to exhibit structural/functional differences due to the possible effects of years dealing with their speech deficit, common in AWS. In this study, subtle volumetric differences in brain white and gray matter (wm, gm) growth in three groups of children differing in stuttering status (children with persistent developmental stuttering (P), those recovered naturally from stuttering (R), and normally fluent children (N)) were compared with voxel-based morphometry (VBM), an unbiased, whole-brain based morphometric MRI technique. Results show interesting differences in wm, gm volume growth in the three groups. P and R exhibited similar structural anomalies when contrasted to N in several cortical and subcortical regions such as the left inferior frontal area, bilateral temporoparietal regions involved in sensory as well as sensorimotor integration, and areas in the basal ganglia and thalamus. However, R differed markedly from P in several cortical as well as cerebellar region tissue growth, which may indicate structural bases of natural recovery from stuttering. Structural bases for stuttering persistence and recovery, their relationship to normal gm and wm tissue growth in childhood and early adolescence, and implications for therapeutic approaches to stuttering will be discussed.
Supported by Univ of Illinois Res Brd grant # 04253, NIH R01 DC 05210
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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