Neuroscience 2003 Abstract
| Presentation Number: | 518.10 |
|---|---|
| Abstract Title: | Ampakines improve cognitive performance after sleep deprivation in nonhuman primates. |
| Authors: |
Hampson, R. E.*1
; Porrino, L. J.1
; Miller, M.1
; Daunais, J. B.1
; Morgan, A. R.1
; West, C. L.1
; Rogers, G. A.2
; Deadwyler, S. A.1
1Dept. Physiol & Pharmacol, Wake Forest Univ. Hlth. Sci., Winston-Salem, NC 2CA, Med. Ctr. Blvd, 27157-1083, |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Learning & memory: Pharmacology |
| Session: |
518. Learning & Memory: Physiology & Imaging I Poster |
| Presentation Time: | Monday, November 10, 2003 2:00 PM-3:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # BB1 |
| Keywords: | MACAQUE, PET, HIPPOCAMPUS, MEMORY |
We have developed a model that allows imaging of the brain effects of sleep deprivation on cognitive performance in nonhuman primates. Utilizing a visual delayed-match-to-sample (DMS) task (Hampson et al. SFN Abstr. v.28, #477.3, 2002), rhesus macaque monkeys were trained to respond to a high overall level (80%) of performance, then individually sleep-deprived for 30-36 hours using a combination of distracters (lighting, music, videos, food, toys) and tested the next day during a session in which 18Fluroxyglucose was injected for PET imaging by positron emission tomography (PET). Performance accuracy on the task was significantly reduced by 15-25%, and reaction times slowed by at least 50% in all monkeys. Scalp EEG showed power spectrum shifts indicative of sleep states during task performance. Global rates of glucose utilization were elevated with regional increases evident in anterior cingulate, prefrontal, parietal and temporal corticies as well as amygdala, assessed while sleep deprived monkeys performed the task. Administration of the ampakine CX717 (Cortex Pharmaceuticals) at doses <1.0 mg/kg prior to and during the session completely reversed the effects of sleep-deprivation on performance. In addition, EEG changes as well regional rates of glucose utilization elevated by sleep deprivation, showed no differences during sessions in which CX717 was administered from non-sleep deprived levels. Thus, the ampakine CX717 not only reversed, but restored normal performance in animals that were disrupted by the effects of prolonged sleep deprivation.
Supported by NIH DA00119, DA06634, DARPA (ARO) #43278-LS, and Cortex Pharmaceuticals
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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