Neuroscience 2004 Abstract
| Presentation Number: | 535.9 |
|---|---|
| Abstract Title: | Preferential activation of the motor region of the dentate nucleus for visually guided reaching movements. |
| Authors: |
Picard, N.*
; Strick, P. L.1
1VAMC, Pittsburgh, PA |
| Primary Theme and Topics |
Motor Systems - Cerebellum -- Cortex and nuclei |
| Session: |
535. Cerebellum I Poster |
| Presentation Time: | Monday, October 25, 2004 1:00 PM-2:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # Z24 |
| Keywords: | cerebellum, primate, 2-deoxyglucose |
Separate regions of the dentate nucleus project via the thalamus to motor and non-motor areas of the cerebral cortex (Dum & Strick, J Neurophysiol. 2003). Consistent with the results of anatomical studies, we previously showed that the motor core of the dentate is functionally activated in monkeys performing reaching movements (Picard and Strick, SFN Abstr. 2002). Here, we extend our analysis to compare relative levels of activation in the motor region of the dentate during performance of internally-guided movements and during performance of similar movements guided by vision. We examined the patterns of 2-deoxyglucose (2DG) uptake in the cerebellum of monkeys trained to perform either sequential reaching movements to visual targets (Random task), or learned sequences of reaching movements performed without visual cues (Repeating task) for liquid rewards. Other animals simply licked liquid rewards but did not perform arm movements. In the dentate nucleus, comparable patterns of activation related to reward consumption were present in all animals. However, the region of the dentate that is connected to the arm representation of the motor areas of the frontal lobe showed small but consistent differences of 2DG uptake during the Random and Repeating tasks. In this region (ipsilateral to the reaching arm), activation was ~8% greater during the Random task. These observations are compatible with the preferential activity for movements guided by vision observed in ~30% of task-related neurons in the dentate nucleus during similar tasks (Mushiake and Strick, 1993). These observations suggest that some of the cerebellar output is enhanced during performance of visually-guided movements.
Supported by VA Med. Res. Serv. (PLS), and NIH grants NS24328 and NS044393 (PLS).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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