Neuroscience 2001 Abstract
| Presentation Number: | 575.10 |
|---|---|
| Abstract Title: | Effects of Supplementary Eye Field Microstimulation on Performance in the Countermanding Paradigm. |
| Authors: |
Stuphorn, V.*1
; Brown, J. W.1
; Schall, J. D.1
1Psychology Dept, Vanderbilt Univ, Nashville, TN |
| Primary Theme and Topics |
Motor Systems - Oculomotor -- Saccadic eye movement |
| Secondary Theme and Topics | Motor Systems<br />- Cortex and Thalamus<br />-- Physiology |
| Session: |
575. Oculomotor: saccadic eye movements Slide |
| Presentation Time: | Tuesday, November 13, 2001 3:15 PM-3:30 PM |
| Location: | Room 7B |
| Keywords: | saccade, control, frontal cortex, monkey |
The countermanding task probes both monkeys' and humans' ability to control behavior by requiring them to withhold planned movements and estimates the time needed to cancel the movement. To succeed in this task, subjects must control their performance. This laboratory has used the countermanding task to study the frontal eye field (FEF)(Hanes et al., J.Neurophysiol. 79:817, 1998), the supplementary eye field (SEF)(Stuphorn et al, Nature 408:857, 2000) and the anterior cingulate cortex (ACC) (Stuphorn and Schall, SfN Abstract 26:404.5, 2000) of macaque monkeys. While neurons in the FEF generated signals sufficient to control saccade production, neurons in the SEF and ACC registered the occurrence of errors and reward. To test the hypothesis, that SEF is part of a supervisory executive control system, we determined the effects of microstimulation (300 ms train, biphasic, 0.2 ms pulsewidth, 333 Hz) on countermanding performance in macaque monkeys. For each stimulation site, we first determined the current threshold for evoking saccades. Current strength was then set to <50% of the threshold value (5-20 uA). In the countermanding task one target was located in the movement field of the evoked saccades. The location of the other one was 180 deg opposite. We stimulated during one quarter of the trials in which a stop signal was presented, beginning 0, 50, 150 and 200 ms after the stop signal. Microstimulation of some sites in SEF enabled the monkey to control saccade initiation more effectively, yielding a higher fraction of cancelled saccades. This result is consistent with the hypothesis that SEF contributes to self-control of oculomotor behavior.
Supported by RO1-MH55806 and DFG
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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