Neuroscience 2001 Abstract
| Presentation Number: | 553.3 |
|---|---|
| Abstract Title: | AUTOANTIBODIES TO AMPA RECEPTORS IN CHILDREN WHITH NON-EPILEPTIC PAROXYSMAL DISORDERS. |
| Authors: |
Globa, O. V.*1
; Sorokina, E. G.1
; Karkashadze, G. A.1
; Shelkovsky, V. I.1
; Studenikin, V. M.1
; Maslova, O. I.1
; Pinelis, V. G.1
1Neurol Diseases Membranol, Scientific Center of children Health,RAMS, Moscow, Russian Federation |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Epilepsy -- Human studies and animal models |
| Session: |
553. Epilepsy: human studies and animal models II Poster |
| Presentation Time: | Tuesday, November 13, 2001 10:00 AM-11:00 AM |
| Location: | Exhibit Hall YY-59 |
| Keywords: | ANTIBODY, EPILEPSY, GLUTAMATE |
There is currently a large difficulties in diagnostic in children who present with loss of consiousness, falls or other paroxysmal motor phenomena. However in 10-20% of children with paroxysmal disorders the epilepsy develops in several months later. The mechanisms of these injuries are currently not well understood. Glutamate-calcium cascade can play the important role in these disorders. It was shown that a damage of glutamatergic neurons results in the appearanse of autoantibodies (aAB) to glutamate (AMPA) receptors. Previously we established increase of the aAB level in children with epilepsy (ELISA method) (SFN abstracts, 1996). The objective of the present work was to estimate the aAB level in children with different non-epileptic fits. The aAB level was the greatest in 74% children with febrile convulsions (FC). In 21% of children with FC having the high level of aAB the convulsions were repeated. We supposed that the damages of glutamate receptors in FC responsible for the mesial-temporal scleroses formation. In children with other non-epileptic paroxysms the level of aAB was lower than in epileptic one (p<0.05), but was higher than in control group. The increase level of aAB was observed in children with faints, migraine, reflex anoxic seizures, isolated seizures and it increased in 6-36 months after the onset of paroxysms. In 21% of children with enhance level of aAB the typical epileptic seizures and specific spikes on EEG was observed in 3-12 months after the examination. Thus data obtained shows the important role of ishemic processes in brain which may leads to symptomatic epilepsies.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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