Neuroscience 2005 Abstract
| Presentation Number: | 454.1 |
|---|---|
| Abstract Title: | Hippocampal volumetrics and region of interest methodology in MRI: identifying homogeneous observations in an inhomogeneous environment. |
| Authors: |
Sullivan, K. A.*1
; Worth, A. J.1
; Wilbur, J.1
; Kennedy, D. N.
; Makris, N.
1Neuromorphometrics, Inc. , Somerville, MA |
| Primary Theme and Topics |
Techniques in Neuroscience - Bioinformatics |
| Session: |
454. Imaging by MRI and PET I Poster |
| Presentation Time: | Monday, November 14, 2005 8:00 AM-9:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # VV46 |
| Keywords: |
Hippocampal volumetrics are important for studying disease progression and diagnosis of temporal lobe epilepsy, Alzheimer’s disease and schizophrenia. However, comparing volumetric variation across studies is difficult due to differing anatomical boundaries, subject characteristics, statistical analyses and image processing techniques. One approach to this problem is to create a database of the homogeneous aspects of studies to increase uniformity and get comparative results. The Internet Brain Volume Database (IBVD) was created to provide a comparison of the various aspects of volumetric studies. As an example of this approach, the current study evaluates normal ranges of volumes in the hippocampus across published studies with similar manual methods and anatomical boundaries. The purpose was to compare and evaluate region of interest (ROI) methods of volumetric analysis and generate a summary of trends and results. Twenty-two peer-reviewed studies involving ROI measurements of the hippocampus were surveyed for their methods and were selected if they included the hippocampal formation as the anatomical boundary and a figural image of the boundary in the research article. This approach was chosen to reduce confusion over anatomical boundaries of the hippocampus and to compare a more homogeneous sample. Other sources of variance were also compared including subject characteristics, image processing techniques and volumetric software. Our results suggest a wide variance of volumes across studies for normal ranges of hippocampal volumes. These results summarize and emphasize that anatomical boundaries, subject characteristics, slice thickness, image processing and image analysis all affect volumetric measurements and should be carefully reported in manuscripts and compared among studies.
Supported by NIH(NIMH) R44 MH60507, NIH(NINDS) NS34189
<B>Conflict of Interest:</B> K.A. Sullivan and A.J. Worth are employees of Neuromorphometrics, Inc.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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