Neuroscience 2002 Abstract
| Presentation Number: | 498.1 |
|---|---|
| Abstract Title: | Neuroanatomical Substrates of Altered d-Amphetamine Response in Major Depressive Disorder (MDD): A Pharmacological Functional Magnetic Resonance Imaging (F-MRI) study. |
| Authors: |
Tremblay, L. K.*1
; Naranjo , C. A.2
; Graham , S. J.3
; Herrmann , N.4
; Mayberg , H. S.4
; Busto , U.1
1Pharmaceutical Sci., U. of Toronto, Toronto, Canada 2Pharmacology , U. of Toronto , Toronto, Canada 3 , U. of Toronto , Toronto, Canada 4 , U. of Toronto , Toronto, Canada |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Affective Disorders |
| Session: |
498. Psychiatric disorders: affective disorders--imaging studies Poster |
| Presentation Time: | Tuesday, November 5, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 Z-32 |
| Keywords: | Depression , Dopamine , Amphetamine , Reward |
An enhanced response to d-amphetamine’s rewarding effects was found in MDD subjects in a previous study, suggesting the presence of a brain reward system dysfunction. In the present study, we performed f-MRI to localize the neuroanatomical substrates of the altered response to 30 mg d-amph p.o. in 6 depressed patients (mean HAMD=28; 3m, 3f; mean age=31) and 6 controls (3m, 3f; Mean age=32). F-MRI data were acquired at baseline and peak d-amph effect (1.5h to 2h). Subjects performed a battery of tasks at both time-points, followed by drug effect self-report measures (e.g. Addiction Research Centre Inventory). Pre-drug f-MRI data acquired during a simple task (i.e. pressing a button following series of visual cues) were contrasted with post-drug f-MRI data from the same task within each subject. ANOVA tests revealed that the depressed patients showed d-amph induced increased activation relative to controls in the anterior cingulate (rostral ACC/area 32)(t =3.18 uncorrected p < 0.01), a region involved in emotional processes and a region that contains dopaminergic neurons. A 2.56% increase in the BOLD (Blood Oxygen Level Dependent) signal occurred in this region within the depressed patients, compared to a –2.59% decrease in the controls. These results suggest that d-amph produced a reliable BOLD signal and may suggest possible neuroanatomical correlates of MDD symptoms such as anhedonia.
Supported by Canadian Institute of Health Research
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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