Neuroscience 2002 Abstract
| Presentation Number: | 496.6 |
|---|---|
| Abstract Title: | DISC-1: Its function and possible IMPLICATION FOR mental illnesses. |
| Authors: |
Ozeki, Y.*1
; Fujii, K.1
; Kleiderlein, J. J.1
; Park, U.1
; Luo, X.1
; Kamiya, A.2
; Yamada, N.2
; Ohkawa, M.2
; Snyder, S. H.1
; Ross, C. A.1
; A. Sawa1
1Dept of Neuroscience and Psychiatry, Johns Hopkins University, Baltimore, MD 2Shiga University of Medical Science, Otsu, Japan |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Schizophrenia |
| Session: |
496. Psychiatric disorders: schizophrenia--animal models II Poster |
| Presentation Time: | Tuesday, November 5, 2002 9:00 AM-10:00 AM |
| Location: | Hall A2-B3 Y-65 |
| Keywords: | DISC-1, Schizophrenia, Nudel, Developing Brains |
There has been growing evidence that DISC-1 (Disrupted-in-Schizophrenia) may be a candidate gene for psychiatric illnesses. We reported the existence of DISC-1 protein in the brain and its protein interaction with molecules which are important in neurodevelopment (Ozeki et al, Kamiya et al, SFN 2001). We have analyzed DISC-1 protein expression in more detail. Its expression is more remarkable in developing brains than adult brains. In adults, DISC-1 displays a specified expression in olfactory bulb. In cellular models, DISC-1 protein expression is induced in PC12 cells upon its differentiation. We have examined intracellular distribution of DISC-1 by immunofluorescent staining and biochemical subcellular fractionation. DISC-1 displays a unique intracellular distribution, including perinuclear regions, consistent with the localization of a DISC-1 interactor, NUDEL. We have analyzed functions of DISC-1 using cellular models by modulating its expression levels via overexpression or knocking down expression by RNAi to DISC-1. In COS cells, overexpression of DISC-1 induces atypical process formation. These results suggest a physiological role of DISC-1 in neurodevelopment, especially neural migration. We are studying DISC-1 in psychiatric illnesses associated with neurodevelopment.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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