Neuroscience 2004 Abstract
| Presentation Number: | 427.20 |
|---|---|
| Abstract Title: | Central representation of cognitive responses during nonnutritive gastric distension: A correlation analysis. |
| Authors: |
Stephan, E.*1
; Hartman, B. K.1
; Faris, P. L.1
; Kim, S.1
; Ivanov, E. H.1
; Iversen, L. R.1
; Daughters, R. S.1
; Costello, P. A.1
; Goodale, R. L.2
; Pardo, J. V.1,3
1Psychiatry, Univeristy of Minnesota, Minneapolis, MN 2Surgery, Univeristy of Minnesota, Minneapolis, MN 3MN, Box 392 Mayo, 55455, |
| Primary Theme and Topics |
Homeostatic and Neuroendocrine Systems - Regulation of Food Intake and Body Weight -- Integration of peripheral signals |
| Secondary Theme and Topics | Homeostatic and Neuroendocrine Systems<br />- Gastrointestinal and urogenital regulation |
| Session: |
427. Peripheral Signals: Reproductive Hormones and Other Poster |
| Presentation Time: | Monday, October 25, 2004 11:00 AM-12:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # FF14 |
| Keywords: | brain, vagus, satiety |
We have recently studied cognitive processing as well as regional cerebral blood flow (rCBF) during non-nutritive gastric distension (Stephan E et al., [Abstract] Annual Meeting of the SfN, New Orleans, LA, November 2003; Stephan E et al., J Gastrointest Surg 2003,7:740).
In this study, we examined the correlation of cognitive responses to and brain circuits involved in gastric balloon distension. In 18 healthy young women, we estimated rCBF with positron emission tomography (15O-water) and recorded cognitive responses on six visual analog scales (VAS) during gastric balloon inflation and deflation. Cognitive responses were recorded for fullness (target sensation), hunger, sleepiness, nausea, gastric discomfort, and tension. We are currently working on correlation analyses of areas of brain activation with VAS data. Results will be interpreted with respect to the concept of interoception (Craig AD, Nat Rev Neurosci,3:655) and within the framework of orbital and medial prefrontal cortical connections (öngür D & Price JL, Cereb Cortex 2000,10:206).
Knowledge about activation areas in the brain associated with cognitive processing of non-nutritive gastric distension can help establish a link between visceral sensation and the abnormal eating patterns reported in eating disorders as well as in obesity and could ultimately lead to alternative therapies.
In this study, we examined the correlation of cognitive responses to and brain circuits involved in gastric balloon distension. In 18 healthy young women, we estimated rCBF with positron emission tomography (15O-water) and recorded cognitive responses on six visual analog scales (VAS) during gastric balloon inflation and deflation. Cognitive responses were recorded for fullness (target sensation), hunger, sleepiness, nausea, gastric discomfort, and tension. We are currently working on correlation analyses of areas of brain activation with VAS data. Results will be interpreted with respect to the concept of interoception (Craig AD, Nat Rev Neurosci,3:655) and within the framework of orbital and medial prefrontal cortical connections (öngür D & Price JL, Cereb Cortex 2000,10:206).
Knowledge about activation areas in the brain associated with cognitive processing of non-nutritive gastric distension can help establish a link between visceral sensation and the abnormal eating patterns reported in eating disorders as well as in obesity and could ultimately lead to alternative therapies.
Supported by Mark A. Nugent Foundation; NIDDK: 5P30 DK50456-08; ORWH: R01-DK52291; NARSAD; Department of Veterans Affairs
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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