Neuroscience 2003 Abstract
| Presentation Number: | 400.29 |
|---|---|
| Abstract Title: | Identification of learning, memory and cognitive function of marginal division in human neostriatum: fMRI and MRI analyses. |
| Authors: |
Wu, Y. M.*1
; Wen, Z. B.1
; Shu, S. Y-.1
; Bao, X. M.1
; Huang, F. H.1
; Li, C. K.1
1Inst. for NeurSci., Guangzhou, China |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Learning and memory |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition and Behavior<br />-- Executive function: Working memory |
| Session: |
400. Learning & Memory II Poster |
| Presentation Time: | Monday, November 10, 2003 8:00 AM-9:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # K8 |
| Keywords: | learning and memroy, cognitive function, human brain, neostriatum |
A special area, the marginal division (MrD), has been found at the caudomedial border of rat striatum in 1988 by Shu et al. It consists of fusiform neurons and is densely filled of many neuropeptide fibers and terminals. The MrD has been also identified in the neostriatum of cat, monkey and human brains. Learning and memory function of the MrD has been verified by Y-maze test in rats.
In order to investigate the function of the MrD in human brain, functional magnetic resonance imaging (fMRI) of healthy volunteers tested with an auditory digital working memory task was performed. Highly active areas were observed in the prefrontal cortex and MrD with left sided predominance during performance of the task, but other parts of the neostriatum were not excited and the MrD was not activated in a control test of non-working memory. The results indicate that the MrD participate the auditory digital working memory of human brain.
Clinical case investigation combining MRI and cognitive function analyses exhibited that the MrD has been involved in the cognitive function. Cognitive function of the dementia patients was evaluated by Mini-Mental State Examination (MMSE). 20 cases with deficiency of cognitive function has been found lesions in the MrD or including the MrD. Statistic analyses showed the bigger of the lesion part, the worse of the cognitive function.
Therefore, both the data from fMRI of healthy human brains and MRI of dementia patients¡| brains proved that the MrD is involved in learning, memory and cognitive function of the brain.
Sponsorship:
Si Yun Shu, M.D.
In order to investigate the function of the MrD in human brain, functional magnetic resonance imaging (fMRI) of healthy volunteers tested with an auditory digital working memory task was performed. Highly active areas were observed in the prefrontal cortex and MrD with left sided predominance during performance of the task, but other parts of the neostriatum were not excited and the MrD was not activated in a control test of non-working memory. The results indicate that the MrD participate the auditory digital working memory of human brain.
Clinical case investigation combining MRI and cognitive function analyses exhibited that the MrD has been involved in the cognitive function. Cognitive function of the dementia patients was evaluated by Mini-Mental State Examination (MMSE). 20 cases with deficiency of cognitive function has been found lesions in the MrD or including the MrD. Statistic analyses showed the bigger of the lesion part, the worse of the cognitive function.
Therefore, both the data from fMRI of healthy human brains and MRI of dementia patients¡| brains proved that the MrD is involved in learning, memory and cognitive function of the brain.
Sponsorship:
Si Yun Shu, M.D.
Supported by NSFC 30070249 and 30270431, and NSFG 013069.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
Copyright © 2003-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
