Neuroscience 2002 Abstract
| Presentation Number: | 44.13 |
|---|---|
| Abstract Title: | REGIONAL AND SUBCELLULAR CHANGES OF GLUTAMATE TRANSPORTER EXPRESSION IN FOCAL CORTICAL DYSPLASIA. |
| Authors: |
Furuta, A.*1
; Rothstein, J. D.2
; Iwaki, T.1
1Dept Neuropathol, Kyushu Univ Grad Sch Med Sci, Fukuoka , Japan 2Dept Neurology, Johns Hopkins Univ, Baltimore, MD |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Transporters -- Glutamate |
| Session: |
44. Transporters: glutamate Poster |
| Presentation Time: | Sunday, November 3, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 D-100 |
| Keywords: | epilepsy, EAAT1, EAAT2, EAAT3 |
Glutamate transporters are thought to have a role for preventing the glutamate excitotoxicity in the epilepsy. We previously demonstrated that glutamate transporter subtypes exhibited dynamic changes in the kainate-induced rat epilepsy (SFN 31st Annual Meeting abstract 815.5, 2001). In the present study, we examined the expressions of glial glutamate transporters, EAAT1 and EAAT2, as well as neuronal glutamate transporter EAAT3 in the human epileptic tissue, focal cortical dysplasia (FCD) which belongs to migration disorders of human cerebral cortex. The surgically resected tissue from the nine cases with FCD (age 2 to 65 years, Palmini grade 2 to 3) were used for immunohistochemistry. Diffuse neuropil staining of EAAT2 was retained or increased in the dysplastic cortex except one case. A majority of subcortical reactive astrocytes were immunoreactive for EAAT2, but negative for EAAT1. Thus, EAAT2 is responsible to uptake the extracellular glutamate in the dysplastic cortex. Dysplastic neurons showed intense immunoreaction for EAAT3 in the perikarya and the perinuclear vesicles. The finding was consistent with the EAAC1 translocation to the Golgi complex in the large pyramidal neurons of the kainate-induced rat epilepsy. The changes of subcellular localization of EAAT3 protein in dysplastic neurons may have a role for preventing excessive uptake or reverse transport of glutamate.
Supported by the Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports Science and Technology (No. 13680824)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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