Neuroscience 2000 Abstract
| Presentation Number: | 455.17 |
|---|---|
| Abstract Title: | Overlap of cortical regions related to auditory and visual processing in the primate mapped with 2-[<SUP>14</SUP>C]deoxyglucose. |
| Authors: |
Poremba, A.*1
; Saunders, R. C.1
; Crane, A. M.3
; Alitto, H. J.1
; Cook, M.2
; Sokoloff, L.2
; Mishkin, M.1
1Lab. of Neuropsychology, NIMH, Bethesda, 2Lab. of Cerebral Metabolism, NIMH, Bethesda, 3Visual Neuroscience Lab., Univ. of Texas, Austin, |
| Primary Theme and Topics |
F. Sensory Systems - 85. Multisensory processing |
| Secondary Theme and Topics | I. Neural Basis of Behavior<br />- 105. Cognition: higher functions |
| Session: |
455. Multisensory processing Poster |
| Presentation Time: | Tuesday, November 7, 2000 8:00 AM-9:00 AM |
| Location: | Hall G-J |
| Keywords: | Convergence, Prefrontal Cortex, Multisensory, Inferior Parictal Cortex |
The cerebral areas involved in audition and vision in the awake rhesus monkey (Macaca mulatta) were identified with the 2-[14C]deoxyglucose (2-DG) method (Poremba et al., SFN Abstr. 25:571.18, 1999; Macko et al., Science 218:394-7,1982). Glucose utilization was determined in intact hemispheres and in hemispheres deafferented from auditory or visual input during auditory or visual stimulation. The experimental groups consisted of 1) monkeys with unilateral auditory deafferentation achieved by unilateral ablation of the inferior colliculus together with transection of the corpus callosum, and the anterior, posterior, and tectal commissures; and 2) monkeys with unilateral visual deafferentation achieved by unilateral optic tract cut with transection of the corpus callosum and the anterior commissure. Animals in the first group passively listened to a wide variety of auditory stimuli and in the second group passively viewed visual stimuli during the 2-DG uptake period of 45 minutes. The results delineate the boundaries and patterns of auditory and visual processing, with each system organized into dorsal and ventral processing streams that proceed to prefrontal cortex. Comparison of these sensory-driven circuits reveals several regions of functional convergence. Preliminary findings identify parts of the inferior parietal lobule, upper bank of the superior temporal sulcus, parahippocampal gyrus, ventral bank of the principal sulcus, and the inferior and orbital prefrontal cortex as cortical regions with functional multimodal processing. These cortical regions are likely to be crucial for sensory integration, including such complex cognitive processes as social communication.
Supported by (NIMH IRP).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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