Neuroscience 2001 Abstract
| Presentation Number: | 463.9 |
|---|---|
| Abstract Title: | REGIONAL REDUCTIONS IN GRAY MATTER DENSITY IN COGNITIVELY NORMAL APOLIPOPROTEIN E (APOE) ε4 HOMOZYGOTES (HM) AND HETEROZYGOTES (HT) USING VOXEL-BASED MRI MORPHOMETRY. |
| Authors: |
Alexander, G. E.*1
; Chen, K.3
; Reiman, E. M.3
; Caselli, R. J.2
; Lewis, D.1
; Frost, J.3
; Bandy, D.3
1Ariz State Univ, Tempe, AZ 2Mayo Clinic, Scottsdale, AZ 3Banner Health Med Ctr, Phoenix, AZ |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimers Disease: Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Neurodegenerative Disorders<br />-- Alzheimers Disease: Cognative function |
| Session: |
463. Neurodegenerative disorders: Alzheimer's disease--pathology and imaging Slide |
| Presentation Time: | Tuesday, November 13, 2001 10:00 AM-10:15 AM |
| Location: | Room 30C |
| Keywords: | ALZHEIMER, NEUROIMAGING, COGNITION, HUMAN |
Cognitively normal APOE ε4 carriers have lower measurements of regional glucose metabolism than ε4 noncarriers (NC; Reiman et al, NEJM 1996; PNAS 2001). To evaluate the effects of APOE ε4 on regional gray matter atrophy in cognitively normal individuals, we compared 11 ε4 HM's (age=55±4yr; 3M/8F) and 11 HT's (age=55±3yr; 3M/8F) with reported family histories of Alzheimer's disease (AD) and no cognitive problems or complaints to 22 demographically-matched NC's (age=56±5yr; 6M/16F) using voxel-based morphometry with T1-weighted MRI's. SPM99 procedures optimized to remove scalp artifact transformed the brain images into coordinates of a standard brain atlas to create a statistical map of group differences in gray matter density. Compared to NC's, the HM's showed significant reductions of gray matter in vicinities of bilateral parahippocampal (PH), posterior cingulate, bilateral parietal (Par), and right (R) frontal regions (3.1≦z≦3.6). The HT's had lower gray matter densities in left (L) PH, anterior cingulate, and R mid-temporal regions (3.3≦z≦4.1) than NC's. Compared to HT's, the HM's had greater gray matter reductions in L PH/lingual and bilateral Par regions (3.3≦z≦3.7). Less gray matter in L Par (p≦0.007) and L PH/lingual (p≦0.03) areas was correlated with worse memory scores in the ε4 carriers. APOE ε4 is associated with reductions in gray matter density in cortical association and paralimbic areas that correlate with cognitive performance and are consistent with the early effects of AD.
Supported by NIH MH57899-01A1, HCR ManorCare, Ariz Alzheimer Res Ctr
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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