Neuroscience 2002 Abstract
| Presentation Number: | 466.7 |
|---|---|
| Abstract Title: | T-588, A NOVEL NEUROPROTECTIVE CHEMICAL COMPOUND, PROMOTES MOTONEURON SURVIVAL AFTER FACIAL NERVE AVULSION OF ADULT RATS. |
| Authors: |
Ikeda, K.*1,2,3
; Watabe, K.2
; Sakamoto, T.2
; Iwasaki, Y.3
; Kinoshita, M.3
; Marubuchi, S.4
; Ono, S.4
; Nakagawa, M.4
1Dept of Neurol, PL Tokyo Health Care Center, Tokyo, Japan 2Molec Neuropathol, Metropolitan Inst Neurosci, Tokyo, Japan 34th Dept of Internal Med, Toho Univ Ohashi Hospital, Tokyo, Japan 42nd Research Dept, Toyama Chemical Co Ltd, Toyama, Japan |
| Primary Theme and Topics |
Motor Systems - Motoneurons |
| Session: |
466. Motoneurons: plasticity Poster |
| Presentation Time: | Tuesday, November 5, 2002 10:00 AM-11:00 AM |
| Location: | Hall A2-B3 L-4 |
| Keywords: | NERVE INJURY, T-588, NEUROPROTECTION, MOTOR NEURON |
T-588, a small molecular compound (MW 330), is developed for neurodegenerative diseases. Clinical trials of T-588 are underway in Alzheimer's senile dementia. This agent has been proven to possess neuroprotection in various studies (Ono S. et al., SFN 1998; Takuma K. et al., Eur. J. Pharm., 2000), and we also have reported that T-588 delays the progression of wobbler mouse motoneuron disease (Brain Res, 2000). Here we evaluated whether T-588 can protect motoneurons following facial nerve avulsion. The right facial nerve was avulsed at the stylomastoid foramen in Fischer 344 male rats (12-14 weeks old ). Rats drank 0.05 % T-588 solution or vehicle for 1, 3 or 4 weeks (each n= 10). During experiment, serum levels of T-588 were approximately 80 ng/ml. At 3 and 4 weeks following avulsion, the lower pons was stained with cresyl-violet. The number of facial motoneurons was counted and the survival ratio (the number of lesion side/that of non-lesion side X 100 %) was determined. At 1 week after avulsion, choline acetyltransferase (ChAT) activities were measured in extracts of the facial nerve nucleus. T-588 treatment inhibited motoneuron death (P<0.01) and potentiated ChAT activities in the facial nerve nucleus. T-588 promotes survival of injured motoneurons and can support motoneuronal function after facial nerve avulsion of adult rats. This compound may have therapeutic potential in motor nerve injury or motoneuron degeneration.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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