Neuroscience 2002 Abstract
| Presentation Number: | 464.6 |
|---|---|
| Abstract Title: | ANTERIOR CINGULATE CORTEX: ERROR-RELATED ACTIVITY IN THE COUNTERMANDING PARADIGM. |
| Authors: |
Ito, S.*1
; Stuphorn, V.1
; Brown, J.2
; Schall, J. D.1
1Psychology, Vanderbilt University, Nashville, TN 2Psychology, Washington University, St. Louis, MO |
| Primary Theme and Topics |
Motor Systems - Oculomotor -- Saccadic eye movement |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Executive function |
| Session: |
464. Oculomotor: cortex Poster |
| Presentation Time: | Tuesday, November 5, 2002 9:00 AM-10:00 AM |
| Location: | Hall A2-B3 K-3 |
| Keywords: | saccade, control, frontal cortex, monkey |
The countermanding task probes monkeys' ability to control behavior by requiring them to withhold planned movements. To succeed in this task monkeys must monitor and control their performance. This laboratory has used the countermanding task to study the function of three frontal areas. Cells in frontal eye field (FEF) generate signals sufficient to control the production of saccades (Hanes et al., J Neurophysiol 79:817, 1998). In contrast, neurons in supplementary eye field (SEF) register the occurrence of errors, conflict, and reward (Stuphorn et al., Nature 408:857,2000). We also recorded from anterior cingulate cortex (ACC) of two macaque monkeys performing the countermanding task, since the ACC is believed to be the source of behavioral monitoring in humans. Indeed we found signals that monitor performance similar to the neurons in SEF (Stuphorn and Schall, SfN Abstract 26:404.5, 2000). Here we report that one particular group of these neurons showed an increase of activity after non-canceled saccades indicating the occurrence of a performance error. In the majority of error-related cells (~80%) the increase was phasic lasting 200-300 ms. In a minority of cells (~20%) the increase was tonic, continuing until the beginning of the following trial. None of the error-related cells recorded so far allowed the prediction of future performance of the monkey. These findings are in accordance with the literature on performance monitoring in the ACC of humans. These data further support the hypothesis that the ACC and the SEF form a cortical network for the executive control of oculomotor behavior.
Supported by RO1-MH55806 and DFG STU 272/1-1
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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