Neuroscience 2002 Abstract
| Presentation Number: | 462.15 |
|---|---|
| Abstract Title: | CEREBRO-CEREBELLAR ACTIVATION DURING MOTOR TASKS. |
| Authors: |
Picard, N.*2
; Strick, P. L.1,2,3
1VAMC, Pittsburgh, PA 2Center for the Neural Basis of Cognition & Dept. of Neurobiology, Univ. of Pittsburgh, Pittsburgh, PA 3Psychiatry & Neurological Surgery, Univ. of Pittsburgh, Pittsburgh, PA |
| Primary Theme and Topics |
Motor Systems - Cerebellum -- Cortex |
| Session: |
462. Cerebellum: functional organization Poster |
| Presentation Time: | Tuesday, November 5, 2002 10:00 AM-11:00 AM |
| Location: | Hall A2-B3 J-2 |
| Keywords: | MONKEY, DENTATE, DEOXYGLUCOSE, TOPOGRAPHY |
Separate 'loops' interconnect the dentate nucleus of the cerebellum with multiple cortical areas in the frontal lobe. In fact, discrete regions of the dentate project via the thalamus to specific motor and non-motor areas (Dum and Strick, SFN Abstr., 2002). To explore the functional correlate of this topographic organization we examined patterns of 2-deoxyglucose (2DG) uptake in behaving monkeys. The monkeys were trained to perform either a licking task (n=2) or visually-guided reaching movements for fluid reward (n=2). These tasks generated clear patterns of activation in multiple areas of the cerebral cortex. For example, the licking task activated the face areas of M1 and the SMA. Intense 2DG uptake was additionally present in the arm representation of a number of motor areas in the frontal lobe during the reaching task. In the dentate, we found patterns of activation that were consistent with the patterns of cortical activation. For example, in licking animals, we found activation in dentate regions that project to the face area of M1 and other premotor areas. Similarly, in reaching animals, we found additional activations in dentate regions that project to the arm area of M1 and other premotor areas. These results suggest that the individual elements in cerebro-cerebellar circuits are co-activated during some motor tasks.
Supported by VA Med. Res. & Rehab. Res. & Develop. Serv. (PLS), and NS24328 (PLS)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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