Neuroscience 2005 Abstract
| Presentation Number: | 410.14 |
|---|---|
| Abstract Title: | Double dissociation of anatomical-behavioral specialization using MRI. |
| Authors: |
Lu, L. H.*1
; Leonard, C. M.2
; Thompson, P. M.1
; Kan, E.1
; Jolley, J.1
; Toga, A. W.1
; Sowell, E. R.1
1Lab of Neuro Imaging, Neurology, UCLA, LA, CA 2FL, 710 Westwood Plaza, Rm 4-238, 90095, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Anatomy |
| Session: |
410. Anatomy and Individual Differences Poster |
| Presentation Time: | Monday, November 14, 2005 9:00 AM-10:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # EE20 |
| Keywords: | cortical thickness, language, motor |
In order to determine if gray matter thickening in the left inferior frontal cortex was related specifically to the maturation of language skills rather than representing a general developmental change nonspecific to language, we examined whether thickening of this region was correlated with phonological processing but not with hand skills. Such specificity would illustrate double dissociation of developmental functional anatomy. We studied 45 normally developing children (between ages 5 and 11) over two years. We analyzed structural MRI data using cortical pattern matching methods, and correlated within-individual changes in thickness to two behavioral scores: Phonological processing (PHONO) and motor performance (MOTOR). White areas of the figure represent positive correlation between change in gray matter thickness and behavioral scores. In red are areas of negative Pearson's r. As predicted, improving PHONO score was associated with gray matter thickening in the left inferior frontal cortex. By contrast, MOTOR improvement was associated with thinning in the left dorsal frontal region. Thickening of the left inferior frontal cortex is associated with improvement of language skills. These results demonstrate the successful application of the concept of double dissociation to developmental changes in brain-behavior relations. This technique can be used to infer functional specialization of anatomical areas and to initiate understanding of structural changes that underlie skill maturation.
Supported by NIDA R21 DA15878 and RO1 DA017831, March of Dimes, 5FY03-12 (ERS); NCRR P41 RR13642 and U54 RR021813, NINDS NS3753 (AWT); and DCD 0922D (CML)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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