Neuroscience 2003 Abstract
| Presentation Number: | 369.13 |
|---|---|
| Abstract Title: | Differential activity-dependent plasticity of the slow afterhyperpolarization evoked by tetanic vs. theta-burst stimulation in CA1 pyramidal neurons: a role for the hyperpolarization-activated cation conductance. |
| Authors: |
Kaczorowski, C. C.*1,2
; Disterhoft, J. F.1
; Spruston, N.2
1Deptartment of Physiology, Northwestern Univ. Med. Sch., Chicago, IL 2IL, 303 East Chicago Ave, 60611-3008, |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Ion Channels -- Potassium channel - Calcium activated |
| Secondary Theme and Topics | Synaptic Transmission and Excitability<br />- Ion Channels<br />-- IH and other channels |
| Session: |
369. Ion Channels: IH & Other Channels Poster |
| Presentation Time: | Monday, November 10, 2003 8:00 AM-9:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # E44 |
| Keywords: | CALCIUM-ACTIVATED POTASSIUM CURRENT, H CURRENT, HIPPOCAMPUS, RAT |
A burst of action potentials in hippocampal neurons is followed by a slow afterhyperpolarization (AHP) that serves to limit firing in response to sustained excitation. Previous studies in our laboratory have shown that the pattern of action potential firing can influence the magnitude and stability of the slow AHP (SFN Abstract, 2002). Here we present the results of studies addressing a potential role for hyperpolarization-activated (H) channels in plasticity of the slow AHP. Whole-cell recordings were obtained from CA1 pyramidal neurons in hippocampal slices from young rats (14-24 days) and action potentials were evoked by brief current injections in 50 Hz trains or a theta-burst pattern (50 spikes per trial). The slow AHP evoked by 50 Hz trains (train-AHP) gradually increased over the course of an experiment, whereas the slow AHP evoked by theta stimulation (theta-AHP) gradually decreased. Application of the H-channel blocker ZD7288 (25 µM) blocked the enhancement of the train-AHP after repeated stimulation (control, 135±18% baseline, n=3; ZD, 85±12 % baseline, n=4), but did not affect the decrease of the theta-AHP (control; 54±12%, n=5; ZD, 58±22%, n=4). These data suggest that an activity-induced downregulation of H channels may underlie the enhancement in the train-AHP, but not the decrease of the theta-AHP.
Supported by NIH AG-08796, NS-35180 & AG-20418
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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