Neuroscience 2002 Abstract
| Presentation Number: | 443.7 |
|---|---|
| Abstract Title: | Activation of β-adrenergic receptors enhances heterosynaptic plasticity at hippocampal CA1 synapses. |
| Authors: |
Yen, C. D.*1
; Yang, H. W.2
; Lin, Y. W.3
; Yang, C. S.4
; Wang, H. J.1
; Chiu, T. H.3
; Min, M. Y.1
1Physiol., Chinese Med. Col., Taichung, Taiwan Republic of China 2Life Sci., Chung Shan Med. Univ., Taichung, Taiwan Republic of China 3Physiol., Ntl. Yang Ming Univ., Taipei, Taiwan Republic of China 4Biomed. Sci., Hung-Kuang Inst. Tech., Taichung, Taiwan Republic of China |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Synaptic Plasticity -- Long-term potentiation (LTP) |
| Session: |
443. Synaptic plasticity: long-term potentiation VII Poster |
| Presentation Time: | Tuesday, November 5, 2002 10:00 AM-11:00 AM |
| Location: | Hall A2-B3 E-6 |
| Keywords: | LTP, LTD, isoproteperol, rats |
In this study, we wish to test the role of β-adrenergic receptors in modulating associated-LTP & LTD induced at a weak synaptic input of Shaffer collateral fibers onto CA1 pyramidal cells, after it was paired with a separated strong Shaffer collateral input in hippocampal slices. The experimental procedures were same as a paper presented in this meeting (Lin et at, SFN 2002 Annul Meeting). As shown in the Figure, bath application of 1 μM isoproterenol (Iso) resulted in LTP of weak input after paired with a strong input with +15 ms (weak leaded strong) delay; this pairing protocol however resulted in no LTP of the weak input in control condition. Application of Iso did not significantly changed LTP induced by pairing protocol of +10 ms delay. In contrast, LTD of weak input was induced by pairing protocol of -100 ms (strong leaded weak) delay in control condition; it was blocked upon application of Iso. The above effects of Iso on LTP & LTD were prevented in slices pretreated with H-89. Our results therefore suggested that activation of β-adrenergic receptors could enhance associated-LTP but block LTD via activation of PKA.
Supported by NSC90-2320-B-039-026 & CMC Hospital
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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