Neuroscience 2004 Abstract
| Presentation Number: | 354.15 |
|---|---|
| Abstract Title: | Positive effects of systemically active galanin receptor agonists in rodent preclincal tests of antidepressant activity. |
| Authors: |
Barr, A. M.*1
; Lu, X.1
; Kinney, J. W.1
; Lucero, J.1
; Haberhauer, G.2
; Trembleau, L.2
; Ceide, S.2
; Somogyi, L.2
; Rebek, J.2
; Bartfai, T.1
1Dept Neuropharmacology, Scripps Res. Inst., La Jolla, CA 2The Skaggs Inst. for Chem. Biol., Scripps Res. Inst., La Jolla, CA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Affective disorders--Experimental pharmacotherapeutics |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Behavioral Pharmacology<br />-- Neuropeptides and behavior |
| Session: |
354. Affective Disorders: Experimental Therapeutics I Poster |
| Presentation Time: | Sunday, October 24, 2004 3:00 PM-4:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # CCC16 |
| Keywords: | DEPRESSION, NEUROPEPTIDE, BEHAVIOR, DRUG |
Neuropeptide receptors have recently become targets for novel antidepressants. The receptors of the neuropeptide galanin may represent a promising target for the development of putative antidepressants, given galanin’s anatomical localization and role in regulation of homeostatic and motivated behaviors. We have recently shown that treatment with three different antidepressant modalities – electroconvulsive shock, sleep deprivation and SSRI – increase levels of galanin mRNA throughout the rat brain (X. Lu et al., SFN abstract 851.10, 2003). Presently, we determined the effects of two systemically-active, low molecular weight galanin receptor agonists, galnon and galmic, on behavior in preclinical tests of antidepressant activity in rats and mice. Galnon displayed a clear dose-dependent effect in the forced swim test in rats, whereby the two highest doses of the drug (20, 40 mg/kg, i.p.) produced a significant increase in time spent active in the task. Similarly, a dose of galmic (15 mg/kg, i.p.) produced antidepressant like activity in the forced swim test. Treatment with identical doses of galnon and galmic in the open field test confirmed that the increased activity in the forced swim test was not due to a stimulant-like general increase in locomotor activity. Current studies are determining the effects of galnon/galmic in the tail suspension test in mice. Receptor binding studies in cell lines expressing galanin receptor subtypes demonstrated that galnon and galmic bind to galanin receptors and suggest that the antidepressant-like behavioral effects of these drugs may be generated at the galanin receptors.
Supported by RO1 MH63080-02
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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