Neuroscience 2004 Abstract
| Presentation Number: | 338.11 |
|---|---|
| Abstract Title: | <I>in vivo</I> evaluation of iron content of mouse models of Alzheimer's disease with quantitative magnetic resonance imaging. |
| Authors: |
Meadowcroft, M. D.*1,2
; Wang, J.2
; Connor, J. R.1
; Smith, M. B.2
; Yang, Q. X.2
1Neural and Behavioral Sci., The Pennsylvania State Univ. Col. of Med., Hershey, PA 2Ctr. for NMR Res., Dept. of Radiology, The Pennsylvania State Univ. Col. of Med., Hershey, PA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimer's Disease: APP & Presenilin (Ab generation) |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Neurodegenerative Disorders<br />-- Alzheimer's Disease: Experimental models |
| Session: |
338. APP/Presenilin Transgenic Models II Poster |
| Presentation Time: | Sunday, October 24, 2004 3:00 PM-4:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # SS28 |
| Keywords: | MRI, NEURODEGENERATION, FREE RADICAL, MAGNETIC |
Several neurodegenerative disorders such as Alzheimer’s disease (AD) are associated with elevated iron accumulation. It is not currently understood whether the iron accumulation in the AD brain is the cause of the neurodegeneration associated with the disease. Here we use T2 weighted and T2* weighted imaging to render sensitive and accurate R2* mapping for quantitative iron measurement with a 3.0T magnet. The attached figure demonstrates the MR imaging of the mouse brain. The left image is a T2 weighted image and the right a T2* parameter map. Areas high in iron content (such as the Substantia Nigra) show as hypo-intense compared to surrounding tissue. This work aims at in vivo quantitative measurement of the iron content of mice models of Alzheimer’s disease. There is a good correlation between the T2* map and the histochemically iron stained sections. These results will allow for quantitative iron measurement and the development of a calibration curve comparing T2* relaxation times to iron concentration in the mouse brain to facilitate quantification of iron in similar hypo-intensive regions in the Alzheimer’s disease brain.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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