Neuroscience 2004 Abstract
| Presentation Number: | 330.13 |
|---|---|
| Abstract Title: | Dynamic changes in CA3 and CA1 place fields within a recording session in a cue-conflict environment. |
| Authors: |
Rao, G.*1
; Lee, I.1
; Knierim, J. J.1
1Dept Neurobiol & Anat, Univ Texas Med Sch, Houston, TX |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Cognitive learning and memory systems |
| Session: |
330. Mapping and Remapping Poster |
| Presentation Time: | Sunday, October 24, 2004 1:00 PM-2:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # NN10 |
| Keywords: |
In a cue-conflict situation in which local cues on a behavioral track are rotated relative to distal landmarks on the wall, CA1 place cell ensembles were shown to split the representation of the environment, as some place fields rotated CW with distal landmarks and other place fields rotated CCW with the local cues. The CA1 representation also changed within a session, as the place fields frequently altered their firing locations within a 15-lap session (Knierim, J. Neurosci., 2002). The ensemble representation in CA3 has been shown to produce a more coherent response to the cue-conflict environment than CA1, as the majority of CA3 place fields rotated CCW with the local cues (Lee et al., SFN Abstracts, 2003). We investigated whether the CA3 place fields also demonstrate the dynamic changes between laps that were previously seen in CA1. Rats (n = 5) were trained to run on a circular track with 4 textured surfaces on the track (local cues) and 6 distal cues on the wall. Each rat ran 15 laps per session (5 sessions/day); three standard sessions were interleaved with mismatch sessions in which the distal cues and local cues were rotated in opposite directions. The stability in the firing properties of CA1 and CA3 place cells across 15 laps was compared based on observation of the lap-by-lap firing rate distributions of individual cells. In both CA1 and CA3, place cells exhibited dynamic changes in their firing properties across laps in the altered environment. Some place fields abruptly appeared and/or disappeared or shifted to different locations on the track. A larger proportion of instances of place field instability occurred in CA1 (49%, 145/294) than in CA3 (29%, 108/374). It appears that the greater coherence of the CA3 representation is also preserved across laps within a session, although further quantification of these results is necessary to fully characterize these differences in ensemble dynamics.
Supported by R01 NS39456, K02 MH63297
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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