Neuroscience 2004 Abstract
| Presentation Number: | 330.7 |
|---|---|
| Abstract Title: | Mnemonic properties of position-modulated neurons in dorsocaudal medial entorhinal cortex. |
| Authors: |
Hafting, T.*1
; Fyhn, M.1
; Moser, E. I.1
; Moser, M.1
1Ctr Biol Mem, NTNU, Trondheim, Norway |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Associative, nonassociative and skill learning & memory systems |
| Session: |
330. Mapping and Remapping Poster |
| Presentation Time: | Sunday, October 24, 2004 3:00 PM-4:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # NN10 |
| Keywords: | hippocampus, place cell, memory, pattern completion |
A striking feature of hippocampal place cells is their ability to maintain place fields after removal of all information from one sensory modality. This abilitiy suggests that hippocampal activity expresses information stored within the hippocampus in addition to the current sensory input. To determine whether the inertness of hippocampal firing emerges internally in the hippocampus or upstream in the neocortex, we measured the stability of spatial firing in neurons in the entorhinal cortex after room lights were switched off. Rats with tetrodes at the dorsocaudal pole of medial entorhinal cortex were trained to run in a square box until cells with stable multipeaked place fields were identified in layer II or III (Fyhn et al., SfN 2003). Room lights were then turned off while the rat was running in the box with lights on, or lights were turned on if the trial started in darkness. Place fields were followed across several sessions, with the rat resting on a pedestal between sessions. Place fields in entorhinal neurons were maintained in spite of total darkness, even across trials. Rotation of the box caused rotation of the place fields. These data suggest (i) that firing fields in superficial layers of medial entorhinal cortex persist in spite of severe changes in sensory input, and (ii) that information from other modalities is sufficient to maintain a representation established with the full set of visual cues present. Ongoing experiments test the possibility that the inertness of entorhinal place fields during noisy changes in sensory input depends on hippocampal return projections.
Supported by Norw. Res. Council Ctr. Excellence Grant
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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