Neuroscience 2001 Abstract
| Presentation Number: | 369.9 |
|---|---|
| Abstract Title: | COMBINED TREATMENT OF BDNF AND NT-3 INTO A CHRONIC SPINAL CORD INJURY DEMONSTRATES LIMITED RECOVERY OF FUNCTION. |
| Authors: |
Shumsky, J. S.*1
; Tumolo, M.1
; Tobias, C. A.1
; Hodge, L.1
; Giszter, S. F.1
; Murray, M.1
1Department of Neurobiology & Anatomy, MCP Hahnemann University, Philadelphia, PA |
| Primary Theme and Topics |
Development - Transplantation and Regeneration -- Transplantation |
| Session: |
369. Transplantation and regeneration: transplantation II Poster |
| Presentation Time: | Monday, November 12, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall C-73 |
| Keywords: | Hyperalgesia, Neurotrophic Factor, Posture, Transplant |
Neurotrophic factors have been demonstrated to rescue damaged axons and thereby promote recovery of function in acute models of spinal cord injury. Here we transplanted fibroblasts genetically modified to express brain-derived neurotrophic factor (BDNF) or neurotrophic factor-3 (NT-3) into a chronic spinal cord injury (see Tobias et al., SFN Abstr 01). Adult rats received a complete C3/C4 hemisection and behavioral recovery was assessed over 5 weeks. The following week they then received control transplants of gel foam or gel foam with unmodified fibroblasts (operated controls), or a combination of fibroblasts modified to secrete either BDNF or NT-3 (experimentals). Behavioral recovery was assessed over the next 10 weeks. Experimental rats showed recovery from heat-induced hyperalgesia and postural adjustment deficits. Similar levels of recovery between groups were observed in the grid test, a sensitive measure of corticospinal function, and the Von Frey test, a measure of mechanical allodynia. In both operated control and experimental rats, no recovery was observed in a variety of tests (BBB, limb preference, narrow beam, rope test) that measure a range of sensorimotor function. The limited recovery observed in such a severe chronic injury model suggests that cell therapy with neurotrophic factors provides a basis for functional recovery. Furthermore, delivery of neurotrophic factors from transplanted fibroblasts does not worsen nociceptive responses.
Supported by ISRT, NIH Grant NS 24707, and EPVA.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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