Neuroscience 2005 Abstract
| Presentation Number: | 308.14 |
|---|---|
| Abstract Title: | rTMS during wakefulness induces a local increase in EEG slow wave activity during subsequent sleep. |
| Authors: |
Huber, R.*1
; Esser, S. K.1
; Massimini, M.1
; Ferrarelli, F.1
; Peterson, M. J.1
; Tononi, G.1
1Psychiatry Dept., Univ. of Wisconsin, Madison, WI |
| Primary Theme and Topics |
Homeostatic and Neuroendocrine Systems - Biological Rhythms and Sleep -- Sleep |
| Session: |
308. Sleep Systems Poster |
| Presentation Time: | Sunday, November 13, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # MM21 |
| Keywords: | plasticity, potentiation, power spectral analysis, homeostasis |
Recent work has shown that rTMS applied to motor cortex can produce changes in muscle motor evoked potentials lasting up to one hour. In an accompanying abstract, we show that rTMS of left motor cortex induces a localized potentiation of TMS-evoked cortical responses (Esser et al., SFN abstract 2005). Here we investigate whether rTMS induced potentiation performed during wakefulness produces lasting effects on EEG spontaneous activity recorded during subsequent sleep. Briefly, using a 60 channel TMS/EEG system with infrared stereotaxic positioning, we performed an rTMS potentiation protocol (1500 rTMS pulses, at 5 Hz, block design, 90% of motor threshold, left motor cortex hand area, 20 minutes session in the evening, n=4 subjects). TMS test stimuli showed an increase in the magnitude of cortical responses (101.1±23.9%) for a cluster of electrodes located slightly caudal and lateral to the site of stimulation. Immediately after the rTMS session, subjects were reclined and allowed to sleep while the EEG was continuously recorded for 1-h. The sleep EEG was staged, subjected to semi-automatic artifact removal and processed using power spectral analysis (4-s epochs, FFT routine, Hanning window). For anatomical localization, EEG electrodes were digitized and co-registered with each subject’s magnetic resonance image (MRI). When the first half hour of sleep was compared to the second half hour, all subjects showed a prominent increase of EEG power (80.5±10.2%) in the lower slow-wave activity (SWA) frequency range (0.5-1 Hz) in a cluster of left parietal electrodes. MRI-aided co-registration localized the increase in SWA to Brodmann areas 2 and 3, near the site of maximum potentiation during wakefulness. Together with our recent demonstration that SWA homeostasis could be triggered by a learning task involving specific brain regions (Huber et al., 2004), these results provide further evidence for the local regulation of SWA homeostasis and support a role for sleep at the cellular level.
Supported by SSMBS and NIMH
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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