Neuroscience 2005 Abstract
| Presentation Number: | 291.24 |
|---|---|
| Abstract Title: | Central and systemic administrations of scopolamine-hydrobromide and scopolamine-methylbromide exert bidirectional effects in rodent models of nociception: implications for traditional medicine. |
| Authors: |
Busha, D. A.*1
; Insixiengmay, M.1
; Kerns, G.1
; Koch, K.1
; Krohn, K.1
; Wunsch, C.3
; Yousef, D.1
; Wiertelak, E. P.1,2
1Neuroscience, Macalester Col., St Paul, MN 2Psychology, Macalester Col., St Paul, MN 3MN, 1600 Grand Ave, 55105, |
| Primary Theme and Topics |
Sensory and Motor Systems - Pain -- Pain models |
| Secondary Theme and Topics | Sensory and Motor Systems<br />- Pain<br />-- Descending modulation |
| Session: |
291. Nocieptive Processing: Modulation Poster |
| Presentation Time: | Sunday, November 13, 2005 4:00 PM-5:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # CC15 |
| Keywords: |
Plants in the Solenace family have a history of use in traditional medicine for pain relief. We have shown that extracts from these plants induce significant and varying effects in rodent models of nociceptive responsivity [SFN 2004, 519.5], presumably resulting from the actions of anti-cholinergic alkaloids (i.e. scopolamine and atropine) found in such plants. Specifically, in rats, these extracts cause decreases in responsivity in hot-plate assays of thermal nociceptive response, increases in responsivity in tail-flick assays of spinal nociceptive responsivity, and both increases and decreases in specific nociceptive behaviors in the formalin assay of responsivity to a chronic, chemical irritant.
The current study examined the effects of pure scopolamine-hydrobromide and scopolamine-methylbromide on nociceptive responsivity. Results show that systemic administrations of pure scopolamine-hydrobromide cause significant, dose-dependent nociceptive alterations paralleling results from whole-plant extracts. Further investigation suggests these effects result from scopolamine’s (and potentially other alkaloids) multiple actions on central and peripheral nociceptive circuitry. Systemically administered scopolamine-methylbromide (peripherally restricted) consistently increased nociceptive responsivity (in the aforementioned assays) and also caused decreases in nociceptive responsivity in the same assays when centrally administered via I.C.V. cannulae. These results suggest the effects of Solenace plants, containing anti-cholinergic alkaloids, are a result of their action on centrally-mediated, cholinergic pain mechanisms. Further investigation of these mechanisms may illuminate how these plants operate as therapeutics for pain and may lead to development of novel, non-opiate based pain treatments.
The current study examined the effects of pure scopolamine-hydrobromide and scopolamine-methylbromide on nociceptive responsivity. Results show that systemic administrations of pure scopolamine-hydrobromide cause significant, dose-dependent nociceptive alterations paralleling results from whole-plant extracts. Further investigation suggests these effects result from scopolamine’s (and potentially other alkaloids) multiple actions on central and peripheral nociceptive circuitry. Systemically administered scopolamine-methylbromide (peripherally restricted) consistently increased nociceptive responsivity (in the aforementioned assays) and also caused decreases in nociceptive responsivity in the same assays when centrally administered via I.C.V. cannulae. These results suggest the effects of Solenace plants, containing anti-cholinergic alkaloids, are a result of their action on centrally-mediated, cholinergic pain mechanisms. Further investigation of these mechanisms may illuminate how these plants operate as therapeutics for pain and may lead to development of novel, non-opiate based pain treatments.
Supported by NCCAM 1R15AT002705-01 to EPW
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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