Neuroscience 2001 Abstract
| Presentation Number: | 323.15 |
|---|---|
| Abstract Title: | Ultra-high field magnetic resonance imaging signal intensity change in Alzheimer's disease. |
| Authors: |
Whitaker, C. D. S.*1
; Schmalbrock, P. M. F.1
; Dashner, R. A.4
; Beversdorf, D. Q.2
; Santi, M. S.3
; Abduljalil, A. M.1
; Truong, T. K.1
; Kangarlu, A.1
; DePhilip, R. M.4
; Kuret, J.5
; Chakeres, D. W.1
; Scharre, D. W.2
1Radiology, The Ohio State University, Columbus, OH 2Neurology, The Ohio State University, Columbus, OH 3Pathology, The Ohio State University, Columbus, OH 4Cell Biology, The Ohio State University, Columbus, OH 5Ctr for Biotechnology, The Ohio State University, Columbus, OH |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimers Disease: Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Aging<br />-- Other |
| Session: |
323. Neurodegenerative disorders: Alzheimer's disease--imaging and pathology I Poster |
| Presentation Time: | Monday, November 12, 2001 10:00 AM-11:00 AM |
| Location: | Exhibit Hall XX-39 |
| Keywords: | MRI, Alzheimer's disease, dementia |
Ultra-high field magnetic resonance (MR) imaging provides the potential for detection of greater signal contrast associated with brain pathology. In this study, preliminary data were gathered to assess whether the pathology of Alzheimer's disease results in sufficient signal changes to distinguish it from normal brain. T2 images were acquired on an 8 Tesla whole body system of 1 cubic inch slices of hippocampus from human Alzheimer specimens and age/sex-matched normal controls. Two acquisitions with the spin echo sequence using TR=750ms and TE=20 and 50ms were collected. Images were reconstructed off-line using a Silicon Graphics workstation. T2 was then calculated for each pixel and displayed as a map. Regions of interest (3 pixels x 3 pixels) were drawn in hippocampal subregions. There was a significant difference in the T2 signal of the CA1 region sampled between groups (T-test). This suggests that signal intensity may be a useful marker for Alzheimer's disease using ultra-high field MR imaging. This contrasts with previous research attributing in vivo MR signal changes in Alzheimer's disease to resting oxygen levels. Further research will be needed to determine causes of this signal change, the specificity of this finding to Alzheimer's disease, and the sensitivity of this finding for patients with milder disease.
Supported by OSU College of Medicine and Public Health
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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