Neuroscience 2001 Abstract
| Presentation Number: | 323.14 |
|---|---|
| Abstract Title: | MRI-DERIVED ENTORHINAL AND HIPPOCAMPAL VOLUME IN INDIVIDUALS AT RISK FOR ALZHEIMER’S DISEASE. |
| Authors: |
Stoub, T.*1
; Bulgakova, M.1
; deToledo-Morrell, L.1
; Wilson, R.1,2
; Bennett, D.1,2
; Leurgans, S.1
1Neurological Sciences, Rush Univ., Chicago, IL 2Rush Alzheimer's Disease Center, Rush Univ., Chicago, IL |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimers Disease: Other |
| Session: |
323. Neurodegenerative disorders: Alzheimer's disease--imaging and pathology I Poster |
| Presentation Time: | Monday, November 12, 2001 9:00 AM-10:00 AM |
| Location: | Exhibit Hall XX-39 |
| Keywords: | MEMORY, DEGENERATION, IMAGING, IN VIVO |
With high resolution MRI techniques, it is now possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer’s disease (AD). Post mortem pathological studies have implicated the entorhinal cortex (EC) as one of the early sites of involvement in AD. Recent studies have demonstrated that both the EC and the hippocampal formation (HF)are significantly atrophied in patients with mild cognitive impairment(MCI), although there is some controversy as to which of these 2 regions is better at predicting conversion to AD. In the present study, 25 elderly participants diagnosed with MCI were examined with an MRI scan near the time of diagnosis. Follow-up clinical evaluations showed that 8 of the 25 participants converted to AD within 3 years of their initial work-up. Both HF and EC volumes were derived from 1.6 mm, gapless, coronal T1-weighted images taken perpendicular to the long axis of the HF using the Analyze software. To correct for individual differences in brain size, the volumes of regions of interest were divided with total intracranial volume. Converters differed from non-converters in both total EC and HF volume (t=5.80, p<.0001, t=3.07, p=.0054, respectively). In logistic regressions using total EC & HF volume, EC volume was found to be a better predictor of conversion, correctly classifying 100% of participants. These results underscore the early involvement of the EC in AD and demonstrate the potential of sensitive neuroimaging techniques for the development of in vivo anatomical markers.
Supported by AG09466 & AG10161
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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