Neuroscience 2001 Abstract
| Presentation Number: | 306.21 |
|---|---|
| Abstract Title: | LOCAL GATING OF SENSORY INPUT TO A MOTOR SYSTEM. |
| Authors: |
Beenhakker, M. P.*1
; Nusbaum, M. P.1
1Dept Neurosci, Univ Pennsylvania, Philadelphia, PA |
| Primary Theme and Topics |
Motor Systems - Pattern Generation |
| Session: |
306. Pattern generation: circuitry and behavior Poster |
| Presentation Time: | Monday, November 12, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall SS-65 |
| Keywords: | Stomatogastric, Projection Neuron, Central Pattern Generator, Rhythmic Neural Activity |
We are studying how distinct sensory pathways elicit different motor patterns from the multifunctional circuits in the stomatogastric ganglion (STG) of the crab Cancer borealis. Activation of one such pathway, the gastro-pyloric stretch receptor neurons (GPRs), directly modulates the pyloric rhythm and influences gastric mill neurons in the STG (Katz & Harris-Warrick, J Neurosci, 1991). The GPRs also indirectly influence these systems by activating the modulatory projection neurons MCN1 & CPN2 in the commissural ganglia (CoGs) (Blitz & Nusbaum, SFN Abstr, 1996). When GPR is stimulated rhythmically in a behaviorally-relevant pattern, it activates MCN1/CPN2 and thereby elicits a gastric mill rhythm with a cycle period of ~15 seconds, even though this rhythm can cycle faster. We are now determining how GPR influences ongoing gastric mill rhythms, such as the one activated by the mechanosensory pathway projecting through the dorsal posterior oesophageal nerve (DPON: Beenhakker et al, SFN Abstr, 2000). During a DPON-elicited gastric mill rhythm, rhythmic GPR stimulation increases the gastric mill cycle period from ~10 seconds to ~15 seconds. This GPR influence on cycle period occurs within the STG, and not within the CoG onto MCN1, because it persists when the GPR pathway to the CoG is transected. Surprisingly, GPR fails to excite MCN1 during ongoing DPON-elicited gastric mill rhythms, despite its ability to do so before and after these rhythms. This is not the result of a ceiling effect from the increased MCN1 activity that occurs during the gastric mill rhythm. We aim to determine the mechanisms underlying the GPR actions on the gastric mill system and its state-dependent excitation of MCN1.
Supported by NSF IBN 9808356 (MPN)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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