Neuroscience 2004 Abstract
| Presentation Number: | 215.3 |
|---|---|
| Abstract Title: | Manipulation of GABA<sub>A</sub> receptors in central nucleus of amygdala: Effects on social interactions. |
| Authors: |
Wellman, L. L.*1
; Clark, C.2
; Gaertner, B. E.2
; Cole, C. E.2
; Silver, C. C.2
; Gale, K.1,2
; Malkova, L.1,2
1Interdisciplinary Program in Neurosci., Georgetown Univ, Washington, DC 2Dept. of Pharmacol., Georgetown Univ, Washington, DC |
| Primary Theme and Topics |
Cognition and Behavior - Motivation and Emotion |
| Session: |
215. Motivation and Emotion: Social Behavior Poster |
| Presentation Time: | Sunday, October 24, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # RR4 |
| Keywords: | pigtail macaque, muscimol, bicuculline, basolateral amygdala |
Decreased social interactions have been observed following complete bilateral ablation of the amygdala. In pigtail macaque dyads, decreased social interactions have also been observed after the selective blockade of GABAA receptors by bicuculline methiodide (BMI) infused unilaterally in basolateral amygdala (BLA) (Malkova et al., 2003). Conversely, the activation of GABAA receptors by focal infusions of muscimol (MUS) bilaterally in BLA resulted in a significant increase in affiliative social interactions, including grooming (Lower et al., SFN 2002). Here we investigated the role of central nucleus of amygdala (CeN) in social behavior using the same manipulations previously employed in BLA. In a randomized design, one monkey at a time (n=5) in each dyad received BMI, MUS, or saline infusions; drug sessions alternated with baseline sessions and changes in behavior occurring during the 2hr following treatment were compared within animals across sessions. Bilateral BMI had no effect on social interactions, whereas bilateral MUS treatment selectively increased passive contact without increasing active grooming; the NMDA antagonist AP7 exerted a similar effect. These results are distinct from those obtained with injections in BLA. In general the effects in BLA were more dramatic than those evoked from CeN and suggest that there is lower tonic GABA activity in CeN as compared with BLA. Moreover, the pattern of alterations in social behaviors indicate that BLA and CeN have distinct roles in modulating social interactions in primates.
Supported by HD39937, HD42269, MH67414, NS20576
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
Copyright © 2004-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
