Neuroscience 2002 Abstract
| Presentation Number: | 277.5 |
|---|---|
| Abstract Title: | KN-VST (KUMADA & NAKAMURA VISUAL SEARCH TEST) IS A SPLENDID PREFRONTAL MEASURE OF THE PRE-DEMENTED ELDERLY. |
| Authors: |
Nakamura, T.*1
; Kumada, T.2
1Psychiatry, DUSM, Koshigaya, Japan 2Human Science & Biomedical Engineering, AIST, Tsukuba, Japan |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Attention |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Aging<br />-- Physiology |
| Session: |
277. Human cognition and behavior: attention III Poster |
| Presentation Time: | Monday, November 4, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 L-29 |
| Keywords: | ATTENTION, AGING, PREFRONTAL CORTEX, DOPAMINERGIC |
[Objective] I reported that a negative reaction time slope on display size 5 to 10 and a V-shape search function of the task result indicate prefrontal injury (p<0.001)(SFN abstract,26(2): 2232, 2000). In the present study, KN-VST and Wisconsin Card Sorting Test (WCST) were compared, from viewpoints of clinical applicability in the elderly who were substantially pre-demented. [Subjects/Method] Subjects were 31 healthy aged, who volunteered to participate in the University health check program of the elderly, including two suspected of dementia and eight slightly demented. Using 123I-IMP SPECT, sensitivity, specificity, and false positive/ negative rates were compared between KN-VST and WCST.[Result] KN-VST showed a splendid result (Table); higher sensitivity 87.5%/ specificity 86.7%, and lower false positive/ negative rates, while WCST showed much poorer results. [Conclusion] KN-VST has a splendid clinical applicability for detecting frontal lobe damages and has a reliable validity for a frontal lobe screening of the elderly, much better than WCST. A plausible background hypothesis, why the V-shape pattern of KN-VST result should be associated with prefrontal dysfunction, were discussed and focused on an ischemic dysfunction of the prefrontal cortex itself and a mesocortical dopaminergic pathway (A10) in the cortices.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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