Neuroscience 2003 Abstract
| Presentation Number: | 203.15 |
|---|---|
| Abstract Title: | Neurobiological substrates of Alzheimer's disease with psychosis: an exploratory study of structural MRI using a voxel-based morphometric approach. |
| Authors: |
Prasad, K. M. R.*1
; Davis, S. W.1
; Becker, J. T.1
; Keshavan, M. S.1
; Sweet, R. A.1
1Dept. of Psychiatry, Univ. of Pittsburgh, Pittsburgh, PA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimer's Disease: Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Psychiatric Disorders<br />-- Schizophrenia |
| Session: |
203. Alzheimer's Disease: Imaging & Neuropathology Poster |
| Presentation Time: | Sunday, November 9, 2003 10:00 AM-11:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # JJ2 |
| Keywords: |
Background: Psychotic symptoms in AD (AD with psychosis, AD+P) identify a heritable phenotype associated with more rapid deterioration in frontotemporal cognitive functions. Functional imaging and post-mortem studies indicate that AD+P may not be a random consequence of diffuse brain illness, but result from specific regional pathology. To our knowledge, there are no studies employing a voxel-based morphometric (VBM) approach to elucidate the structures that could be abnormal in AD+P.
Objective: To conduct VBM analyses of structural MRIs in subjects with AD+P and matched subjects without psychosis (AD-P).
Methods: Subjects (AD-P=22; AD+P=18) were assessed as part of participation in the Alzheimer Disease Research Center at the University of Pittsburgh. The presence of psychotic symptoms was assessed using the CERAD Behavioral Rating Scale. These groups were matched for age, gender, number of years of education, and duration of AD. Statistical Parametric Mapping (SPM 99) was used for image processing. All images were normalized into stereotactic space, segmented into gray, white and cerebrospinal fluid compartments and smoothed by convolving with a Gaussian smoothing kernel (8x8x8 fwhm). Age, gender and number of years of education were covariates. The preset threshold for identifying suprathreshold voxels was p=0.001. Results: Subjects with AD+P had decreased gray matter concentrations in the left middle frontal gyrus (MFG) compared to subjects with AD-P.
Discussion: Subjects with AD with psychosis demonstrated regionally circumscribed excess gray matter reduction. Additional comparisons with normal subjects, and among psychosis subtypes will be presented.
Objective: To conduct VBM analyses of structural MRIs in subjects with AD+P and matched subjects without psychosis (AD-P).
Methods: Subjects (AD-P=22; AD+P=18) were assessed as part of participation in the Alzheimer Disease Research Center at the University of Pittsburgh. The presence of psychotic symptoms was assessed using the CERAD Behavioral Rating Scale. These groups were matched for age, gender, number of years of education, and duration of AD. Statistical Parametric Mapping (SPM 99) was used for image processing. All images were normalized into stereotactic space, segmented into gray, white and cerebrospinal fluid compartments and smoothed by convolving with a Gaussian smoothing kernel (8x8x8 fwhm). Age, gender and number of years of education were covariates. The preset threshold for identifying suprathreshold voxels was p=0.001. Results: Subjects with AD+P had decreased gray matter concentrations in the left middle frontal gyrus (MFG) compared to subjects with AD-P.
Discussion: Subjects with AD with psychosis demonstrated regionally circumscribed excess gray matter reduction. Additional comparisons with normal subjects, and among psychosis subtypes will be presented.
Supported by AG05133, AG16976, MH066231, and NIMH/APA PMRTP T32 MH19126
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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