Neuroscience 2005 Abstract
| Presentation Number: | 199.20 |
|---|---|
| Abstract Title: | Beneficial effects of vitamin A enriched diet on working memory in aged mice. |
| Authors: |
Mingaud, F.*1
; Mormede, C.1
; Pallet, V.1
; Jaffard, R.2
; Higueret, P.1
; Marighetto, A.2
1Unité de Nutrition et Signalisation Cellulaire USC INRA 2975, Talence cedex, France 2France, Universite Bordeaux 1 venue des Facultes, 33405, |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Aging |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Aging<br />-- Molecular studies |
| Session: |
199. Aging: Sensory, Attentional, and Memory Processes Poster |
| Presentation Time: | Sunday, November 13, 2005 11:00 AM-12:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # NN18 |
| Keywords: | vitamin A enriched diet, cognitive ageing, working memory |
In humans, mnemonic decline associated with senescence is known to preferentially affect declarative and working memory capacities. Using a mouse behavioural model of ageing-related decline in declarative memory, we previously demonstrated that such a specific deficit was alleviated by a systemic treatment with a vitamin A derivative, retinoic acid. Concomitantly, this retinoic acid treatment normalised the ageing-related hypo-expression of the brain (and hippocampal) retinoid signalling pathway. Acting through transcription factors, the retinoids can indeed regulate the expression of a large spectrum of genes including synaptic plasticity-related genes. The present work was aimed at further investigating on possible relationships between memory abilities and brain retinoid signalling pathway during the process of ageing, using a mouse model of ageing-related decline in working memory. Mice were chronically submitted to a vitamin A enriched diet (45 I.U. vs 5 I.U for control groups). Independent subgroups of mice were tested at different ages [either young adult : 3-4 months, middle-age : 9-11 months or aged mice: 20-23 months] and subcutaneously treated with either vehicle or retinoic acid (150µg/kg). Working memory was assessed using a recently designed radial-arm maze task. In control groups, a progressive decline in working memory performance during ageing was observed. This memory decline was significantly reduced in aged mice fed with the 45 I.U. diet or treated with retinoic acid, but not in middle- aged animals. The present study provides further evidence for a significant involvement of vitamin A in cognitive ageing.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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