Neuroscience 2001 Abstract
| Presentation Number: | 214.13 |
|---|---|
| Abstract Title: | A continuing problem: problems continuing after mild head trauma. More kinds of central fatigue? A neuroimmune update. |
| Authors: |
LeFever, F. F.*1
; Hasenkam, J. A.1
1Neuropsychology, Helen Hayes Hosp, West Haverstraw, NY |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Trauma -- Brain |
| Session: |
214. Trauma: brain injury--mechanisms III Poster |
| Presentation Time: | Sunday, November 11, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall YY-13 |
| Keywords: | HEAT SHOCK PROTEIN, AUTOIMMUNITY, ACCUMBENS, MITOCHONDRIA |
Description of neuroimmune responses in physiological rather than psychological, social, forensic concepts of chronic problems after mild head trauma (LeFever, INS 1995) was extended and applied to mental fatigue(LeFever SFN 1996) and stress responses transiently exceeding compensation for low prefrontal and basal ganglia dopamine resources as a basis for typical sporadic exacerbation (LeFever SFN 1998). In this update, to restore unity of motivation, attention, and action seen in old studies of hypothalamic facilitation of goal directed behavior, lost in current specialized research, and account for increased subjective sense of effortful initiation poorly labeled fatigue, we intended introducing a new concept, central fatigue at ventromedial rather than traditional dorsolateral sites, but found it well developed by Chaudhuri & Behan (J. Neurol. Sci. 2000,179: 34-42). Our updates include: antigenic & inflammatory aspects of axonal disruption, beyond brain mast cell activation by myelin basic protein (LeFever 1995,1996), and of heat shock protein/neuronal cross-reactivity; functional alterations in incomplete apoptotic processes; biphasic helpful/harmful response (e.g. to hypoxia)in acute vs. chronic adaptation (cf. female advantage & disadvantage, LeFever SFN 1997); mitochondrial deficit & oxidative metabolic strain in cells stressed but not killed. Deficient prefrontal regulation of brainstem phasic forebrain modulation due to long axon structural vulnerability & metabolic demand converging with vulnerability of frontal origins may be an aspect of central fatigue after mild brain trauma.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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