Neuroscience 2005 Abstract
| Presentation Number: | 114.9 |
|---|---|
| Abstract Title: | Imaging accumbens monoamines with behavior: ketanserin, caffeine, and cocaine interactions. |
| Authors: |
Broderick, P. A.*1,2,3
; Medicherla, R.1
; Zhou, F.1
; Forrester, L. W.1
1Med Prof Physiol & Pharmacol, CUNY Med. School, New York, NY 2NY, Rm Harris01, 10031, 3USA, Rm Harris01, 10031, |
| Primary Theme and Topics |
Disorders of the Nervous System - Addiction and Drugs of Abuse -- Neurobiology of reward |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Addiction and Drugs of Abuse<br />-- Psychostimulants |
| Session: |
114. Neurobiology of Reward Poster |
| Presentation Time: | Saturday, November 12, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # VV88 |
| Keywords: | DOPAMINE, SEROTONIN, VOLTAMMETRY, CARDIOVASCULAR |
We have previously reported (1) that the antihypertensive agent, ketanserin a 5-HT2A/2C antagonist, blocked cocaine-induced accumbens dopamine (DA) and serotonin (5-HT) release simultaneously with behavior (Broderick et al., PNP:2004) and (2) that caffeine exacerbated cocaine's neurochemical and behavioral responses at even low doses (Forrester and Broderick, SFN:2004). The purpose of this paper is to ascertain the effect of ketanserin (3 mg/kg ip) on the neuromolecular interactions between caffeine and cocaine (25 and 5 mg/kg ip, respectively) because of the multifaceted mechanisms of these psychostimulants via adenosine, 5-HT and DA receptors. Neuromolecular imaging (NMI) based on in vivo electrochemistry was used with BRODERICK PROBE® laurate sensors for selective and separate detection of DA and 5-HT in accumbens; infrared photobeams (San Diego Instr.) were used to monitor ambulatory and stereotypic activities at the same time as neurotransmitter signals were detected. The results showed that ketanserin potentiated the DA release, ambulatory and stereotypic responses to caffeine and cocaine (alone and coadministered) while 5-HT release was attenuated. Expectedly, ketanserin, by direct receptor action, increased 5-HT release and by indirect action, increased DA release. The data show that ketanserin was unable to block cocaine-induced DA release in the presence of caffeine, possibly due to 5-HT2A/2C neuromodulation of DA release by caffeine at adenosine receptors. The data are important to the neurobiology of reward as well as to drug addiction. Moreover, the antihypertensive properties of ketanserin may play a role in cocaine dysfunction and critically, this role may differ when caffeine is present. Thus, the data have important implications for the treatment of cardiovascular disease.
Supported by NIH/NIGMS #SO 6 GM 08168; PSC/CUNY RF64282-00-33; The Broderick Brain Foundation, RF75510; Pharmacia and Upjohn/ Pfizer Awards: RF76361-00-01 and RF 76591-00-01.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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