Neuroscience 2002 Abstract
| Presentation Number: | 147.4 |
|---|---|
| Abstract Title: | Dynamics of Fast Spiking interneuron-mediated synaptic inhibition in monkey dorsolateral prefrontal cortex. |
| Authors: |
Gonzalez-Burgos, G.*1
; Krimer, L. S.2
; Barrionuevo, G.1
; Lewis, D. A.1,2
1Neuroscience, University of Pittsburgh, Pittsburgh, PA 2Psychiatry, University of Pittsburgh, Pittsburgh, PA |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Synaptic Transmission -- Postsynaptic mechanisms: Inhibitory |
| Secondary Theme and Topics | Motor Systems<br />- Cortex and Thalamus<br />-- Physiology |
| Session: |
147. Synaptic transmission: postsynaptic mechanisms--inhibitory I Poster |
| Presentation Time: | Sunday, November 3, 2002 4:00 PM-5:00 PM |
| Location: | Hall A2-B3 D-94 |
| Keywords: | WORKING MEMORY, GABA, GABAERGIC, IPSP |
We have previously reported that in slices from adult monkey dorsolateral prefrontal cortex (DLPFC, areas 9 and 46), layers 2/3 Fast Spiking (FS) interneurons have homogeneous membrane properties but can be grouped in at least 4 morphological classes: Local, Medium or Wide Arbor neurons and Chandelier cells (SFN 2001 Abstr 729.14). Despite this diverse morphology, unitary IPSPs (uIPSPs) elicited by FS neurons in pyramidal cells (PCs) have very similar latency, rise time, exponential decay and are GABAA-receptor-mediated, suggesting a similar inhibitory synaptic output (SFN 2001 Abstr 467.4). Here, we report the effects of repetitive firing of different subclasses of FS neurons on the efficacy of uIPSPs elicited in postsynaptic PCs. In every synaptic connection examined to date (n=9), the uIPSPs depressed during 10 spike-20 Hz trains elicited in the FS neuron, as revealed by the IPSP(10)/IPSP(1) ratio. uIPSP depression was strong in some connections and relatively weaker in others. Interestingly, if the presynaptic FS neuron was of the Chandelier class, uIPSPs showed strong depression whereas uIPSPs elicited by the other morphological classes exhibited weaker depression. uIPSP depression was at least in part due to a presynaptic mechanism, since uIPSP failure rate was higher for IPSP(1) than for IPSP(10). These preliminary data indicate that uIPSP dynamics may differ across subclasses of FS neurons, which therefore could play different roles in shaping local circuit dynamics during repetitive firing in DLPFC in vivo.
Supported by MH51234, MH45156, MH63561-01 and a NARSAD Young Investigator Award to G. Gonzalez-Burgos
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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