Neuroscience 2003 Abstract
| Presentation Number: | 87.12 |
|---|---|
| Abstract Title: | Inducible impairment in motor coordination, acquisition, and expression of motor memory. |
| Authors: |
Ikeda, T.*1
; Suzuki, M.2
; Katayama-Morita, M.3
; Kawahara, S.2
; Hashikawa, T.
; Kirino, Y.2
; Itohara, S.1
1Lab. for Behavioral Genet., Brain Sci. Inst., RIKEN, Saitama, Japan 2Japan, Behavioral Genet., BSI, RIKEN Hirosawa 2-1, Wako Saitama, 351-0198 Japan, 351-0198, 3Lab. of Neurobiophysics, Sch. of Pharmaceut. Sci., Behavioral Genet., BSI, RIKEN Hirosawa 2-1, Wako Saitama, 351-0198 Japan, 351-0198, |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Associative, nonassociative and skill learning & memory systems |
| Secondary Theme and Topics | Motor Systems<br />- Cerebellum<br />-- Cortex and nuclei |
| Session: |
87. Human Cognition and Behavior: Eyelid Conditioning Poster |
| Presentation Time: | Saturday, November 8, 2003 4:00 PM-5:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # R9 |
| Keywords: | ASSOCIATIVE LEARNING, CEREBELLUM, MOTOR LEARNING, PURKINJE CELL |
The cerebellum has an essential role in motor coordination and motor learning. To investigate the neural circuit underlying motor learning and the retention of motor memory, we developed a genetic cell-ablation system in the mouse. In this mouse, ligand-induced recombination results in preferential ablation of Purkinje cells. Along with the Purkinje cell loss, these mice exhibited dystonic movement of the feet, severe ataxia, and ligand-dependent impaired performance in the rota-rod test. Eyeblink conditioning was analyzed to further address the role of Purkinje cells in motor learning and the expression of motor memory. In a delay paradigm (cerebellum-dependent associative learning), administration of ligand impaired acquisition of the conditioned response and expression of the acquired conditioned response. In a trace paradigm (hippocampus-dependent associative learning), the acquired conditioned response was also impaired after ligand administration. There was no obvious anatomic abnormality of the ponto-cerebellar pathway in ligand-administered mice. Furthermore, the mice had normal responses to aversive stimuli. These results suggest that Purkinje cells have a crucial role in cerebellar-dependent motor learning, the expression of motor memory, and in the performance of hippocampal-dependent associative motor memory.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
Copyright © 2003-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
