Neuroscience 2004 Abstract
| Presentation Number: | 82.9 |
|---|---|
| Abstract Title: | Cognitive enhancement by ampakines: Characterization of mechanisms in the rat and monkey. |
| Authors: |
Deadwyler, S. A.*1
; Porrino, L. J.1
; Miller, M.1
; Daunais, J. B.1
; Morgan, A. R.1
; West, C. L.1
; Ramirez, S.1
; Rogers, G. A.2
; Hampson, R. E.1
1Dept Physiol & Pharmacol, Wake Forest Univ Sch Med, Winston-Salem, NC 2CA, Med Ctr Blvd, 27157-1083, |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Behavioral Pharmacology<br />-- Other |
| Session: |
82. Cognitive Learning and Memory: Primates Poster |
| Presentation Time: | Saturday, October 23, 2004 1:00 PM-2:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # GG10 |
| Keywords: | PET, BEHAVIOR, LEARNING AND MEMORY, HIPPOCAMPUS |
Prior studies in rats and monkeys have shown that Ampakines can improve performance in cognitive tasks requiring short-term memory (Hampson et al. J. Neurosci. 1998; Hampson et al. SFN Abstr. 2003). In rats performing a spatial delayed-nonmatch-to-sample (DNMS) task, Ampakines increase overall accuracy of performance and enhance trial-specific encoding by CA1 and CA3 neurons. In addition, Ampakines extended performance on DNMS trials to delays that were much longer than those in which the animal was trained (i.e. 60 vs. 30 sec). We have expanded these studies to rhesus macaque monkeys performing a visual delayed-match-to-sample (DMS) task. Ampakines improved monkeys' performance accuracy in the DMS task by 10-20% in a dose-dependent manner, and again, enhanced firing of CA1 and CA3 neurons that encoded information critical to completion of the DMS trial. Multivariate discriminant analyses have identified response latency and accuracy factors during monkey DMS sessions that correlate with the behavioral performance enhancement by the Ampakine. PET imaging of 18Fluroxyglucose uptake during these sessions reveal Ampakine-related changes in brain glucose metabolic activity associated with hippocampus and prefrontal cortex, as the main brain areas involved with performance of the DMS task, and the areas that show enhanced metabolic rates following administration of performance facilitating Ampakines.
Supported by NIDA, DARPA (PSD) and Cortex Pharmaceuticals
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
Copyright © 2004-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
