Neuroscience 2003 Abstract
| Presentation Number: | 79.20 |
|---|---|
| Abstract Title: | Error-related local field potentials in medial frontal lobe of macaques during saccade countermanding. |
| Authors: |
Emeric, E. E.*1
; Stuphorn, V.2
; Schall, J. D.2
1Ctr. for Integrative & Cognitive Neurosci., Vanderbilt Univ., Nashville, TN 2TN, 2201 West End Ave, 37235, |
| Primary Theme and Topics | Motor Systems |
| Secondary Theme and Topics | Cognition and Behavior |
| Session: |
79. Saccades: Physiology & Models II Poster |
| Presentation Time: | Saturday, November 8, 2003 4:00 PM-5:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # I97 |
| Keywords: | OCULOMOTOR, MONKEY, CONTROL, CINGULATE |
A critical function of the human brain is to monitor behavior and prevent undesirable
actions. Evidence suggests that the medial frontal cortex, particularly the anterior
cingulate cortex (ACC), is involved in this action monitoring. Studies of the error-related
negativity (ERN or Ne), a medial frontal negative component of the event-related scalp
potential recorded in humans have contributed to this evidence. The error-related potentials, which peak about 100 ms after an erroneous response, are maximal at frontal-central recording sites. Single unit recordings in SEF and ACC during the countermanding task, a task which manipulates subjects' ability to withhold planned saccades, have revealed distinct populations of neurons that modulate their firing rate in response to errors during the same interval as error-related potentials originating in medial frontal cortex (Stuphorn et al., Nature 408:857; Ito et al., SfN Abstract 28:464.6, 2000). Local field potentials were recorded in SEF and ACC simultaneously with the single units during the countermanding task. In SEF, no clear error-related field potential was observed even at sites where error-related unit activity was recorded. In contrast, in ACC the error-related field potential was found in the majority of the recording sites. However, such error-related field potentials were not present at all sites where error-related unit activity was encountered but could be present at sites without error cells. These findings indicate that error-related field potentials and unit activity are not uniformly co-localized and show a marked difference between SEF and ACC that could explain source localization of the ERN in humans.
actions. Evidence suggests that the medial frontal cortex, particularly the anterior
cingulate cortex (ACC), is involved in this action monitoring. Studies of the error-related
negativity (ERN or Ne), a medial frontal negative component of the event-related scalp
potential recorded in humans have contributed to this evidence. The error-related potentials, which peak about 100 ms after an erroneous response, are maximal at frontal-central recording sites. Single unit recordings in SEF and ACC during the countermanding task, a task which manipulates subjects' ability to withhold planned saccades, have revealed distinct populations of neurons that modulate their firing rate in response to errors during the same interval as error-related potentials originating in medial frontal cortex (Stuphorn et al., Nature 408:857; Ito et al., SfN Abstract 28:464.6, 2000). Local field potentials were recorded in SEF and ACC simultaneously with the single units during the countermanding task. In SEF, no clear error-related field potential was observed even at sites where error-related unit activity was recorded. In contrast, in ACC the error-related field potential was found in the majority of the recording sites. However, such error-related field potentials were not present at all sites where error-related unit activity was encountered but could be present at sites without error cells. These findings indicate that error-related field potentials and unit activity are not uniformly co-localized and show a marked difference between SEF and ACC that could explain source localization of the ERN in humans.
Supported by NIMH R01 and T32.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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