Neuroscience 2000 Abstract
| Presentation Number: | 130.4 |
|---|---|
| Abstract Title: | Distinct effects of acetylcholine on EPSPs of CA1 interneurons. |
| Authors: |
Seeger, T.*1
; Alzheimer, C.1
1Dept Physiology, University of Munich, Munich, Germany |
| Primary Theme and Topics |
C. Excitable Membranes and Synaptic Transmission - 31. Excitatory postsynaptic mechanisms |
| Secondary Theme and Topics | D. Neurotransmitters, Modulators, Transporters, and Receptors<br />- 40. Acetylcholine receptors: muscarinic |
| Session: |
130. Excitatory postsynaptic mechanisms I Poster |
| Presentation Time: | Sunday, November 5, 2000 4:00 PM-5:00 PM |
| Location: | Hall G-J |
| Keywords: | Hippocampus, Nuscarinic, Glutatiate, Carbachol |
Hippocampal interneurons are highly diverse. So far, attempts to define subgroups based on characteristic combinations of morphology, electrophysiology and transmitter sensitivity have failed. Using whole-cell recordings from visually identified CA1 interneurons, we examined the effect of the cholinergic agonist, carbachol (CCh, 20 μM), on EPSP-like waveforms evoked by brief glutamate pulses onto their proximal dendrites in the presence of bicuculline, D-APV and TTX. In interneurons of stratum oriens, CCh consistently reduced these glutamate-induced postsynaptic potentials (GPSPs) by 20 - 60% in an atropine-sensitive manner. The voltage dependence as well as the low Ba2+ (200 μM) sensitivity of this effect suggested that it resulted from the muscarinic activation of a GIRK conductance, as we have recently reported from CA1 pyramidal neurons (SFN Abstr. 25: 899.1, 1999). By contrast, the vast majority of interneurons (86%) recorded in stratum radiatum displayed no increase (43%) or a substantial enhancement of GPSP amplitude (43%) during CCh superfusion, with the non-responders predominantly located towards the subiculum. Our data suggest that the postsynaptic modulation by acetylcholine of excitatory input impinging onto CA1 interneurons might occur in a stratum-specific fashion.
Supported by DFG (SFB 391 A9, and Heisenberg-Program)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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