Neuroscience 2004 Abstract
| Presentation Number: | 13.2 |
|---|---|
| Abstract Title: | Method for obtaining high-resolution transverse relaxation time (T2) maps of individual vermal lobules using 3T phased-array segmented EPI MRI. |
| Authors: |
Anderson, C. M.*1
; Rohan, M. L.1
; Renshaw, P. F.1
; Teicher, M. H.1
1Brain Imag Cntr & Dept Psych, Harvard Med Sch McLean Hosp, Belmont, MA |
| Primary Theme and Topics |
Techniques in Neuroscience - Data analysis, physiological methods, statistics |
| Secondary Theme and Topics | Motor Systems<br />- Cerebellum<br />-- Anatomy |
| Session: |
13. Techniques: Brain Imaging Methods I Slide |
| Presentation Time: | Saturday, October 23, 2004 1:15 PM-1:30 PM |
| Location: | San Diego Convention Center - Room 3 |
| Keywords: | cerebellum, T2 relaxation, vermis, ADHD |
Previously we reported alterations in transverse relaxation times in whole cerebellar vermis of adults with a history of childhood sexual abuse, and children with ADHD following stimulant administration. Preclinical studies, however, indicate functional heterogeneity within the vermis, which extends to individual lobules or lamellae. To study lobular changes in T2, we employed the enhanced S/N afforded by high-field MRI. Using a Siemens 3T Trio scanner with an 8-channel phased-array head coil, segmented EPI (TE/TR = 15, 31…127/6, matrix =256, seg = 8) pixel-wise T2 maps were collected over 7 minutes and calculated for lobule ROIs using least-squares-fit to log-linear data with a single exponential decay model. ROIs of the 10 lobules were drawn using Larsell (1972).
Two subjects (M, 33; F, 21) are imaged to date. The male vermis contained 1445 total voxels, with the following for each lobule (#, T2 in msec): I (18, 80.38); II (57, 66.86); III (101, 64.33); IV (68, 70.93); V (271, 64.40); VI (95, 70.88); VII (247, 62.66); VIII (227, 63.76); IX (125, 58.84); X (111,65.00) and Fastigial Nuc.(125, 67.54). The female vermis was smaller (745 total voxels), & for each lobule: I+II (21, 82.27); III (81, 69.92); IV (52, 72.98); V (134, 72.28); VI (71, 70.5); VII (71, 76.19); VIII (87, 68.14); IX (120, 73.72); X (39,78.86) and Fastigial Nuc.(30, 68.86).
A general inverse correlation between ROI size and T2 was observed for both individuals (R [1,11] = 0.4, p = 0.055) & (R [1,10] = 0.4, p < 0.05), respectably. The pattern of T2 was very consistant between the two subjects for anterior regions (I-VI, 8, FN; R = 0.872), but differed for regions VII, IX & X. T2 maps of cerebellum may enable rapid, repeatable, non-invasive measures of steady-state blood flow changes in psychiatric and pharmacodynamic studies.
Two subjects (M, 33; F, 21) are imaged to date. The male vermis contained 1445 total voxels, with the following for each lobule (#, T2 in msec): I (18, 80.38); II (57, 66.86); III (101, 64.33); IV (68, 70.93); V (271, 64.40); VI (95, 70.88); VII (247, 62.66); VIII (227, 63.76); IX (125, 58.84); X (111,65.00) and Fastigial Nuc.(125, 67.54). The female vermis was smaller (745 total voxels), & for each lobule: I+II (21, 82.27); III (81, 69.92); IV (52, 72.98); V (134, 72.28); VI (71, 70.5); VII (71, 76.19); VIII (87, 68.14); IX (120, 73.72); X (39,78.86) and Fastigial Nuc.(30, 68.86).
A general inverse correlation between ROI size and T2 was observed for both individuals (R [1,11] = 0.4, p = 0.055) & (R [1,10] = 0.4, p < 0.05), respectably. The pattern of T2 was very consistant between the two subjects for anterior regions (I-VI, 8, FN; R = 0.872), but differed for regions VII, IX & X. T2 maps of cerebellum may enable rapid, repeatable, non-invasive measures of steady-state blood flow changes in psychiatric and pharmacodynamic studies.
Supported by DA016222, DA016934, DA09448, DA14178, MH066222
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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