Neuroscience 2005 Abstract
| Presentation Number: | 995.10 |
|---|---|
| Abstract Title: | Effects of septal and temporal hippocampus lesions on spatial memory in a place preference task. |
| Authors: |
Gutnick, T.*1
; Donandt, S.1
; Heinemann, U.1
; de Hoz, L.1
1Inst. for Physiology, Charite, Berlin, Germany |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Session: |
995. Cognitive Learning and Memory Systems: Spatial and Nonspatial Learning and Memory Poster |
| Presentation Time: | Wednesday, November 16, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # KK12 |
| Keywords: |
Experimental evidence for a functional differentiation along the longitudinal axis of the hippocampus (hpc) exist, however, its extent and precise nature remains unclear. Several lesion studies have suggested that the septal (dorsal) hpc is of greater importance in spatial learning, while the temporal (ventral) hpc is involved in non-spatial memory. However, temporal, but not septal, hpc-spared rats show new spatial learning capability in a watermaze, following a preoperative training protocol that required the animals to dwell over a spatial location before the platform became available (Martin and de Hoz, SFN 2003).
In the present study we explore whether this pattern of results can be extended to a spatial appetitive task, the place preference task (Rossier et al., 2000), in which rats were required to dwell in an unmarked but fixed location of a dry land maze before receiving a food reward. The task was adapted to incorporate, like the watermaze study, a reminder within the testing protocol. Food deprived rats received non-spatial cued pretraining during which they learned to dwell. Spatial training took place in an open field maze with distal cues. Rats had to dwell in an unmarked area of the maze before a light was shone briefly over this target zone and a sucrose pellet was released from the ceiling onto a random position in the maze.
Ibotenic acid lesions of either the septal or the temporal 70% of the hpc were performed immediately after training. Memory of the target area was measured during 3 probe trials spaced 1 hour apart. Each probe consisted of 2 min without reward, followed by 30s of reminder: light was shone on the target area and rats were rewarded when they crossed it.
Evidence of memory for the target area was seen in both partial lesioned groups but this was evident at different points of the testing protocol. The results support the idea that the temporal hpc underlies certain aspects of spatial memory.
In the present study we explore whether this pattern of results can be extended to a spatial appetitive task, the place preference task (Rossier et al., 2000), in which rats were required to dwell in an unmarked but fixed location of a dry land maze before receiving a food reward. The task was adapted to incorporate, like the watermaze study, a reminder within the testing protocol. Food deprived rats received non-spatial cued pretraining during which they learned to dwell. Spatial training took place in an open field maze with distal cues. Rats had to dwell in an unmarked area of the maze before a light was shone briefly over this target zone and a sucrose pellet was released from the ceiling onto a random position in the maze.
Ibotenic acid lesions of either the septal or the temporal 70% of the hpc were performed immediately after training. Memory of the target area was measured during 3 probe trials spaced 1 hour apart. Each probe consisted of 2 min without reward, followed by 30s of reminder: light was shone on the target area and rats were rewarded when they crossed it.
Evidence of memory for the target area was seen in both partial lesioned groups but this was evident at different points of the testing protocol. The results support the idea that the temporal hpc underlies certain aspects of spatial memory.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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