Neuroscience 2003 Abstract
| Presentation Number: | 949.15 |
|---|---|
| Abstract Title: | Functional MRI mapping of dopamine receptor-mediated neuronal activity in basal ganglia of parkinsonian monkeys. |
| Authors: |
Zhang, Z.*1,2,3
; Andersen, A.1,2,3
; Loveland, A.1
; Froman, E.1
; Hardy, P.2
; Gash, D. M.1,2,3
1Anat. and neuroBiol., Univ. of Kentucky, Lexington, KY 2MRISC, Univ. of Kentucky, Lexington, KY 3Morris K. Udall PD Res. Ctr. for Excellent, Univ. of Kentucky, Lexington, KY |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Parkinson's Disease: Other |
| Session: |
949. Parkinson's Disease: Other III Poster |
| Presentation Time: | Wednesday, November 12, 2003 3:00 PM-4:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # Z6 |
| Keywords: | FMRI, MONKEY, DOPAMINE RECEPTOR, PARKINSON |
Previously, we have demonstrated that fMRI can be used to map age-associated changes in nigrostriatal system with dopaminergic stimulation in normal rhesus monkeys (NeuroImage 14: 1159-1167, 2001). In the present study, fMRI was used to map dopamine (DA) receptor-mediated blood oxygen level dependent (BOLD) changes indicative of neuronal activity in the basal ganglia of hemiparkinsonian rhesus monkeys. Unilateral infusion of MPTP via the right carotid artery was used to induce unilateral parkinsonian features in 12 monkeys; 3 age-matched normal monkeys served as controls. Apomorphine (APO, 0.1mg/kg s.c.), a mixed dopamine D1/D2 receptor agonist, evoked strong activation in the MPTP-lesioned caudate nucleus, putamen, globus pallidus (GP) and substantia nigra (SN) with little change detected on the intact side of these structures. The activation on the lesioned side persisted in the GP until administration 15 min later of the D1 receptor antagonist (SCH-23390, 0.1mg/kg i.m.). APO-induced activation was reversed, returning to baseline levels in the globus pallidus externa (GPe) and significantly below baseline (negative effects) in the GPi and SN. In contrast, the D2 receptor antagonist (Raclopride, 0.05mg/kg i.m.) did not reverse the activation in the putamen, GPi and SN, but reinforced activation 5 to 10 minutes after the antagonist administration. However, partial blocking and reversal effects were seen in the MPTP-lesioned caudate and GPe after the D2 receptor antagonist administration. These results suggest that fMRI can detect changes in dopamine receptor-mediated neuronal activity in response to D1 and D2 agonists and antagonists in parkinsonian rhesus monkeys, and is useful in mapping functional changes in neural circuitry in the parkinsonian brain.
Supported by AG13494, NS39787, and MH01245
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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