Neuroscience 2003 Abstract
| Presentation Number: | 863.14 |
|---|---|
| Abstract Title: | The reproducibility of functional connectivity MAPs calculated using low frequency correlations in the steady state MRI time series. |
| Authors: |
Skudlarski, P. N.*1
; Driesen, N. R.1
; Wexler, B.1
; Constable, T.1
; Gore, J. C.2
1Diagnos. Radiology, Yale Univ, New Haven, CT 2TN, 300 Cedar St New Haven, 06520-8043, |
| Primary Theme and Topics |
Techniques in Neuroscience - Data analysis, physiological methods, statistics |
| Session: |
863. Imaging Methods Poster |
| Presentation Time: | Wednesday, November 12, 2003 9:00 AM-10:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # VV60 |
| Keywords: | CEREBRAL BLOOD FLOW, BRAIN IMAGING, FUNCTIONAL MRI |
Introduction:
Regional correlations in the low frequency oscillations of the BOLD signal in the MRI time series are of considerable interest. While their neural origins are still not well understood it is believed that those correlations provide a new insights into the functional connectivity of the human brain. Correlations observed in steady states series of MRI images seem to connect distant but functionally connected regions of the brain. They have been shown to be modified by activation conditions. The origin of those correlations is not well understood and their neuronal origin has not yet been definitively proven. The authors believe that they are caused by vasomotion (low frequency oscillations in the blood flow) that is affected by neuronal connections between distant but functionally connected regions of the brain.
Methods:
5 normal control subjects were scanned in two separate sessions. Each study session contained localizer runs that interleaved blocks of working task with control task. These block design runs were used to localize regions involved in working memory processing. The steady state runs were collected while the subject was resting, or, performing continuously the working memory task during the whole run.
The working memory regions were used as seed regions to study the correlations of the low frequency correlations in the steady state fMRI time course. The “similarity” of analogous correlation calculated from the same subjects in different sessions was used to measure reproducibility of this procedure.
Results: The between sessions comparison indicates that correlation maps are reproducible. What is more important the differences between correlation in two brain states is reproducible as well, proving that correlation maps have significant, non random component that is affected by performing the working memory task.
Regional correlations in the low frequency oscillations of the BOLD signal in the MRI time series are of considerable interest. While their neural origins are still not well understood it is believed that those correlations provide a new insights into the functional connectivity of the human brain. Correlations observed in steady states series of MRI images seem to connect distant but functionally connected regions of the brain. They have been shown to be modified by activation conditions. The origin of those correlations is not well understood and their neuronal origin has not yet been definitively proven. The authors believe that they are caused by vasomotion (low frequency oscillations in the blood flow) that is affected by neuronal connections between distant but functionally connected regions of the brain.
Methods:
5 normal control subjects were scanned in two separate sessions. Each study session contained localizer runs that interleaved blocks of working task with control task. These block design runs were used to localize regions involved in working memory processing. The steady state runs were collected while the subject was resting, or, performing continuously the working memory task during the whole run.
The working memory regions were used as seed regions to study the correlations of the low frequency correlations in the steady state fMRI time course. The “similarity” of analogous correlation calculated from the same subjects in different sessions was used to measure reproducibility of this procedure.
Results: The between sessions comparison indicates that correlation maps are reproducible. What is more important the differences between correlation in two brain states is reproducible as well, proving that correlation maps have significant, non random component that is affected by performing the working memory task.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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