Neuroscience 2001 Abstract
| Presentation Number: | 946.21 |
|---|---|
| Abstract Title: | LOSS OF VAGAL IGLE-TYPE MECHANORECEPTORS FROM THE SMALL INTESTINE IN NEUROTROPHIN-4 DEFICIENT MICE DISRUPTS SHORT-TERM SATIETY. |
| Authors: |
Fox, E. A.*1
; Byerly, M. S.1
; Jones, S.1
; Boynton, M.1
; Foldes, S.1
; Powley, T. L.1
1Dept Psycholog Sci, Purdue Univ, West Lafayette, IN |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Regulation of Food Intake and Body Weight |
| Session: |
946. Regulation of food intake and body weight II Poster |
| Presentation Time: | Thursday, November 15, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall NN-11 |
| Keywords: | vagus, NT-4 knockout, food intake, Intraganglionic Laminar Endings |
Intraganglionic laminar endings (IGLEs) are vagal mechanoreceptors associated with the myenteric plexus of the upper GI tract. Interactions of IGLEs with both the neurons and capsules of myenteric ganglia suggest that these endings transduce tension to coordinate smooth muscle function and inform the brain about such activity. We recently found that neurotrophin-4 (NT-4) knockout mice have a selective loss of IGLEs in the small intestine (Fox et al., 2000, SFN meeting). To examine the role of these intestinal mechanoreceptors in ingestive behavior, meal patterns of NT-4 and wild-type mice consuming a novel pelleted (20mg, Bioserv) or liquid (Isocal, Mead Johnson) diet were monitored for two weeks. At the end of the experiment, the vagal dorsal motor nucleus (dmnX; cresyl violet) was examined for neuronal loss. Meal-pattern analysis revealed that after the animals had adapted to the diet and apparatus, meals in the NT-4 knockout mice were twice the duration of control meals for solid, but not liquid diet. However, a reduction in meal frequency maintained normal daily intake and body weight in the mutants, implying that long-term controls of feeding were intact. The histological survey indicated that the dmnX appeared intact in NT-4 mutants, confirming the sensory-specificity of vagal loss. The meal-patterning results suggest that intestinal IGLEs are essential for normal regulation of short-term satiety and for formation of associations between intestinal fill and post-ingestive consequences of a solid diet, probably by conveying feedback about intestinal transit or distension to the brain.
Supported by NIH DK27627
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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