Neuroscience 2001 Abstract
| Presentation Number: | 920.8 |
|---|---|
| Abstract Title: | NOVEL ENVIRONMENTS FACILITATE LONG-TERM POTENTIATION THROUGH 5-HT1A RECEPTORS IN THE DENTATE GYRUS. |
| Authors: |
Davis Hart, C.*1
; Jones, F. L.1
; Derrick, B. E.1
1Dept Life Sciences, Univ Texas At San Antonio, San Antonio, TX |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Synaptic Plasticity -- Long-term potentiation (LTP) |
| Secondary Theme and Topics | Synaptic Transmission and Excitability<br />- Neurotransmitters<br />-- Serotonin |
| Session: |
920. Synaptic plasticity: long-term potentiation IX Poster |
| Presentation Time: | Thursday, November 15, 2001 11:00 AM-12:00 PM |
| Location: | Exhibit Hall F-68 |
| Keywords: | dentate gyrus, Long-term Potentiation, Serotonin, exploration |
Previously, our studies in freely-moving rats demonstrate that the probability, magnitude and longevity of LTP at the medial perforant path-dentate gyrus (DG) synapse are increased when LTP is induced in a novel environment (Davis Hart, SFN,1997). Our studies also indicate this facilitation effect elicited by novelty is independent from beta-adrenergic and muscarinic receptor mediation (Davis Hart, SFN, 2000). However, exposure to novel stimuli activates other neuromodulatory systems, including the serotonergic system (Wilkson, Everitt, 1996). We therefore examined whether the serotonergic system , specifically 5-HT1A receptors, are involved in novelty-induced facilitation of LTP. Perforant path-DG responses were collected daily for 1 week in the home cage until stable baseline responses were established. Following a 15 min collection of baseline responses in the home cage, a selective 5-HT1A receptor antagonist, WAY-100635 (0.5mg/kg, 0.01mg/kg or 0.005mg/kg) or equal volumes of water were administered i.p. Thirty minutes after drug or water administration, animals were placed in a novel environment where LTP was induced using theta burst stimulation. Following tetanus, animals were returned to the home cage and responses were collected for 1 hour. Daily responses were recorded for an additional 2 weeks. WAY-100635 either blocked or attenuated LTP magnitude and longevity in a dose-dependent manner. By contrast, WAY-100635 was ineffective in blocking LTP in the familiar (home) cage, even at the highest dose. Thus, novelty-induced facilitation of LTP is mediated by 5-HT1A receptors and is dependent upon a novel context.
Supported by DA 11983 (BED)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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