Neuroscience 2005 Abstract
| Presentation Number: | 848.10 |
|---|---|
| Abstract Title: | Repeated induction of LTD leads to long-lasting synaptic reduction separate from LTD. |
| Authors: |
Kamikubo, Y.*1
; Tanaka, T.1
; Egashira, Y.1
; Shinoda, Y.1
; Tominaga-Yoshino, K.1
; Ogura, A.1
1Department of Neuroscience, Osaka Univ. Graduate School of Frontier Biosciences, Toyonaka, Japan |
| Primary Theme and Topics |
Neural Excitability, Synapses, and Glia: Cellular Mechanisms - Synaptic Plasticity -- Spines and structural plasticity |
| Session: |
848. Spines and Structural Plasticity III Poster |
| Presentation Time: | Wednesday, November 16, 2005 9:00 AM-10:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # K7 |
| Keywords: | CULTURE, HIPPOCAMPUS, SLICE, MGLUR |
Long-term synaptic plasticity accompanied by rearrangement of synaptic structures is assumed to be the cellular basis of long-term memory. Morphological changes associated with LTP are regarded as precursory phenomena leading to synaptogenesis. However, much less is known about the morphological consequences of LTD, another form of synaptic plasticity in mammalian brain. Recently we reported a long-lasting (i. e. lasting for ≧3 wk) decrease in synaptic strength accompanied by a reduction in the number of synaptic structures after the repetition of transient exposure to ACPD (an mGluR agonist) and APV (an NMDAR antagonist) in stable cultures of hippocampal slice, which treatment induced LTD in this specimen (cf. 2004 SfN Meeting abstract 856.2). This decrease was separate from LTD per se, since the LTD-coupled diminution of EPSP disappeared in <24 hr and another diminution developed gradually after that. Thus we proposed that this phenomenon should represent a new form of long-term synaptic plasticity. It is important in this context to know whether this synaptic reduction is provoked not only after the repeated treatment with ACPD/APV but also after the repeated induction of LTD by any means.
We tested here various means of LTD induction previously reported for acute hippocampal slice preparations in our cultured slice preparations and examined whether the repetition of those means would lead to the long-lasting reduction in the number of synaptic structures. The results were affirmative so that our previous observation of the long-lasting synaptic reduction was not a pharmacological effect specific to ACPD/APV but the general consequence of repeated induction of LTD.
This work was supported by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
We tested here various means of LTD induction previously reported for acute hippocampal slice preparations in our cultured slice preparations and examined whether the repetition of those means would lead to the long-lasting reduction in the number of synaptic structures. The results were affirmative so that our previous observation of the long-lasting synaptic reduction was not a pharmacological effect specific to ACPD/APV but the general consequence of repeated induction of LTD.
This work was supported by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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