Neuroscience 2001 Abstract
| Presentation Number: | 866.6 |
|---|---|
| Abstract Title: | Intraindividual <i>in vivo</i> 3D-MRI volumetry of delayed alterations in human brain volume after cerebral infarction. |
| Authors: |
Kraemer, M.*1
; Schormann, T.2
; Bi, P.1
; Hagemann, G.1
; Zilles, K.2
; Freund, H. J.1
; Seitz, R. J.1
; Witte, O. W.1
1Dept Neurology, Heinrich-Heine-Univ, D-40225 Duesseldorf, Germany 2C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University, D-40225 Duesseldorf, Germany |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Ischemia |
| Session: |
866. Ischemia: cellular and molecular mechanisms XIII Poster |
| Presentation Time: | Wednesday, November 14, 2001 2:00 PM-3:00 PM |
| Location: | Exhibit Hall XX-21 |
| Keywords: | STROKE, MORPHOMETRY, HUMAN, MRI |
In our study, we examined delayed volume changes in remote brain areas in 8 stroke patients with territorial MCA infarction. MRI scans were carried out 7 days and between 3 and 16 months after stroke. The segmented brain MRIs from the same patient at two different times were matched to each other using an extended principal axes theory, generalized to affine movements, a cross-correlation based procedure and a fast automated multiresolution full-multigrid movement model. This method enables exact alignment and reproducibility due to the completely automated procedure. The investigated brains showed remarkable volume reductions in widespread cortical areas remote from the lesion site. Atrophy was also detected in the ipsilateral thalamus and caudate nucleus that were both not affected by ischemia. Secondary brain atrophy was accompanied by an improved score of the European Stroke Scale at the follow-up examination.
Our study demonstrates delayed widespread and locally differential brain atrophy in brain areas remote from the stroke lesion site that does not correlate with the improvement of clinical outcome.
Our study demonstrates delayed widespread and locally differential brain atrophy in brain areas remote from the stroke lesion site that does not correlate with the improvement of clinical outcome.
Supported by SFB 194
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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