Neuroscience 2000 Abstract
| Presentation Number: | 844.1 |
|---|---|
| Abstract Title: | Evaluation of the acquisition, retention and reversal learning of an operant response in various strains of mice. |
| Authors: |
Marquis, K. L.*1
; Brennan, J. A.1
; Rosenzweig-Lipson, S.1
1Wyeth Neuroscience, Wyeth-Ayerst Research, Princeton, NJ |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 107. Learning and memory: systems and functions-animals |
| Secondary Theme and Topics | I. Neural Basis of Behavior<br />- 107. Learning and memory: systems and functions-animals |
| Session: |
844. Learning and memory: systems and functions--mouse sex and strain differences Poster |
| Presentation Time: | Thursday, November 9, 2000 8:00 AM-9:00 AM |
| Location: | Hall G-J |
| Keywords: | DBA2N, C57BL6/N, 129SvEv, Nosepoke |
A rapid response acquisition model for mice contrasting different strains for the acquisition of a food motivated nosepoke response has been described recently (Baron and Meltzer, SFN 25:641, 1999). In that study, 129SvJ and DBA2J mice took a longer time to reach a set number of correct responses compared with CD1 mice. Measures based on latency can be misleading since motoric difference may influence latency. The current study contrasts different strains of mice (DBA2N, CD1, 129SvEv, C57BL6/N) in the acquisition of a nosepoke response employing a response based criterion measure for learning. Mice, restricted to 85% of their initial weight, were evaluated over a four day period. On day 1, 2 hrs of non-contingent presentation of an evaporated milk reward was paired with a houselight on a variable interval 60 sec schedule. On day 2, one of 2 illuminated nosepokes was randomly assigned as correct and reinforced, whereas responses in the other nosepoke were only recorded. The session was terminated when a subject reached a performance criterion of 3 out of 4 consecutive bins of 10 responses with ≥90% correct. Day 3 (retention) employed the same contingencies. On day 4 (reversal), the formerly incorrect nosepoke was reinforced. The rank order of the mean number of responses required to reach criterion performance was determined to be: acquisition and retention - 129<C57<DBA=CD1; reversal -C57<DBA<CD1<129. When the latency to reach criterion was examined, the rank order was determined to be: acquisition - CD1<129=DBA<C57; retention - CD1<129<DBA<C57; reversal -CD1<129<C57<DBA. These data underscore the need to use measures that are not dependent on latency in such complex learning models.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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